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Exogenous triggers of oxidative stress, such as ultraviolet radiation (<jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>) and visible light (<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>), lead to pigment formation through somewhat different pathways, but both share a common endpoint\u2014the potential to generate cosmetically undesirable hyperpigmentation. Though organic and inorganic sunscreens are available to protect against the <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> portion of the electromagnetic spectrum, coverage is lacking to protect against the <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content> spectrum. In this manuscript, we review the phases of tanning, pathways of melanogenesis triggered by <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>, and the associated impact of oxidative stress. We also discuss the known intrinsic mechanisms and paracrine regulation of melanocytes that influence their response to <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>. Understanding these mechanisms and their role in <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\u2010induced hyperpigmentation should potentially lead to identification of useful targets that can be coupled with antioxidant therapy to alleviate this effect.<\/jats:p>","DOI":"10.1111\/phpp.12423","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T12:25:20Z","timestamp":1536582320000},"page":"420-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["The potential role of antioxidants in mitigating skin hyperpigmentation resulting from ultraviolet and visible light\u2010induced oxidative stress"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9766-0149","authenticated-orcid":false,"given":"Amanda F.","family":"Nahhas","sequence":"first","affiliation":[{"name":"Department of Dermatology Beaumont\u2010Farmington Hills  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