{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:43:05Z","timestamp":1790685785391,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2019,7]]},"abstract":"Summary<\/jats:title>Background\/purpose<\/jats:title>Photodynamic therapy (PDT<\/jats:styled-content>) is an established treatment for actinic keratosis (AK<\/jats:styled-content>). Among the approved protocols in Europe, the most widely used involves irradiation with the Aktilite CL<\/jats:styled-content> 128 (C\u2010PDT<\/jats:styled-content>). We aimed to assess the heterogeneity of irradiance over the treatment area when using C\u2010PDT<\/jats:styled-content>. We also investigated whether there is a cut\u2010off value for protoporphyrin IX<\/jats:styled-content> (PpIX<\/jats:styled-content>)\u2010weighted irradiance that may predict the treatment outcome of C\u2010PDT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>An Ophir PD<\/jats:styled-content>300 photodiode sensor connected to an Ophir Laser Star power meter was used to measure the irradiance delivered to 114 AK<\/jats:styled-content>s of the scalp and forehead of 19 patients treated with C\u2010PDT<\/jats:styled-content>. The PpIX<\/jats:styled-content>\u2010weighted irradiances were deduced and cross\u2010referenced with the complete responses at 3\u00a0months.<\/jats:p><\/jats:sec>Results<\/jats:title>From the measured irradiances ranging from 0.25 to 60\u00a0mW\/cm2<\/jats:sup> (average: 31.94\u00a0mW\/cm2<\/jats:sup>), a standard deviation of 17.17\u00a0mW\/cm2<\/jats:sup> was computed. Irradiance heterogeneity over the treatment area during C\u2010PDT<\/jats:styled-content> was demonstrated. The 66\/114 AK<\/jats:styled-content>s with a complete response at 3\u00a0months (57.89%) received a mean PpIX<\/jats:styled-content>\u2010weighted irradiance of 0.52 mW<\/jats:styled-content>\/cm2<\/jats:sup> vs 0.56\u00a0mW<\/jats:styled-content>\/cm2<\/jats:sup> for the resistant 48\/114 AK<\/jats:styled-content>s (42.11%). No significant effect of PpIX<\/jats:styled-content>\u2010weighted irradiance on the complete response at 3\u00a0months was found (odds ratio for a 0.1\u2010unit change, 0.96; 95% confidence interval, 0.83 to 1.10; P\u00a0<\/jats:italic>=\u00a00.53). Therefore, no cut\u2010off value for PpIX<\/jats:styled-content>\u2010weighted irradiance that predicts treatment outcome could be identified.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A device enabling homogeneous irradiation at a lower irradiance than the Aktilite CL<\/jats:styled-content> 128 may therefore be suitable. This lower irradiance may further increase the treatment tolerance by patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12457","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T11:20:24Z","timestamp":1550143224000},"page":"232-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Photodynamic therapy for actinic keratosis of the forehead and scalp with the Aktilite CL<\/scp> 128: Is there a cut\u2010off value for PpIX<\/scp>\u2010weighted irradiance for effective treatment?"],"prefix":"10.1111","volume":"35","author":[{"given":"Claire","family":"Vicentini","sequence":"first","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"},{"name":"Department of Dermatology CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0979-3310","authenticated-orcid":false,"given":"Anne\u2010Sophie","family":"Vignion\u2010Dewalle","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Thecua","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Lecomte","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"B\u00e9hal","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille EA 2694 \u2013 Sant\u00e9 Publique: \u00e9pid\u00e9miologie et qualit\u00e9 des soins Unit\u00e9 de Biostatistiques Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Maire","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"},{"name":"Department of Dermatology CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Baptiste","family":"Tylcz","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Abi\u2010Rached","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"},{"name":"Department of Dermatology CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mortier","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"},{"name":"Department of Dermatology CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Mordon","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille U1189 \u2013 ONCO\u2010THAI \u2013 Image Assisted Laser Therapy for Oncology Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.06.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S1769"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08882.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2570"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366548"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0539-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07470.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.031"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01096.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13138"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.01.020"},{"key":"e_1_2_6_13_1","article-title":"Photodynamic therapy for actinic keratosis of the forehead and scalp: a randomized, controlled, phase II clinical study evaluating the noninferiority of a new protocol involving irradiation with a light\u2010emitting, fabric\u2010based device (the Flexitheralight protocol) compared with the conventional protocol involving irradiation with the Aktilite CL 128 lamp","author":"Vicentini C","year":"2018","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22665"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70113-G"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/b507325a"},{"key":"e_1_2_6_17_1","unstructured":"GALDERMA. Aktilite \u2010 Tailored for PDT.Available at:http:\/\/www.galderma.se\/Portals\/3\/images\/2014\/files\/Brochure%204p_AKTILITE_201303.pdf2013."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11200.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15146"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22827"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.5436"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00116-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00595.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07145.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09096.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2012.00681.x"},{"key":"e_1_2_6_27_1","first-page":"377.","article-title":"PHOS\u2010ISTOS clinical trial: a new solution for photodynamic treatment of actinic keratosis without pain","volume":"50","author":"Vicentini C","year":"2018","journal-title":"Lasers Surg Med"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08451.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10209.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030309"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08450.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510032887"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2012.1896"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2278"}],"container-title":["Photodermatology, Photoimmunology & Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphpp.12457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T17:48:37Z","timestamp":1694281717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/phpp.12457"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12457","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]},"assertion":[{"value":"2018-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}