{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:11:30Z","timestamp":1789866690092,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The main chromophores of human skin are melanins and hemoglobins along with carotenoids, bilirubin, and other compounds. In an effort to study the spectral signatures of skin melanin, we measured absorption spectra in a variety of situations, including a method to show early signs of re\u2010pigmentation in vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To measure skin in vivo, the essential component was a \"Bifurcated Optical Fiber\" with one end connected to the light source and the second end connected to the spectrometer while the common end was placed on the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a typical in situ \u201cmelanin in skin\u201d spectrum, the absorbance values first rise gradually, from 750 to 600\u00a0nm, then rise moderately from 600 to 450\u00a0nm, and rise sharply from 450\u00a0nm to a broad peak at 335\u00a0nm, below which it gradually rolls down to much lower values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We successfully studied melanin spectroscopically in subjects with vitiligo lesions, obtaining the differential spectra. Higher melanin levels can be shown by steeper negative slopes of a straight line fitted between 620 and 720\u00a0nm. Also, absorption peak at 335\u00a0nm showed the presence of melanin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12474","type":"journal-article","created":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T13:18:45Z","timestamp":1555852725000},"page":"415-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Spectroscopic observations on human pigmentation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-1310","authenticated-orcid":false,"given":"Iqbal","family":"Sadiq","sequence":"first","affiliation":[{"name":"Product Investigations Inc. 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