{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T23:46:56Z","timestamp":1750376816237},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a systemic inflammatory disease characterized by hindered antioxidant defense and increased formation of free radicals. There are limited data on the skin carotenoids in psoriatic skin as well as their modulation during narrow\u2010band UVB (NB\u2010UVB) phototherapy of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this prospective study is to reveal the skin carotenoids levels during NB\u2010UVB phototherapy of psoriasis in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Twenty Caucasian subjects with mild\u2010to\u2010moderate plaque psoriasis (15m; 5f) were enrolled in the study, and nine gender\u2010 and age\u2010matched healthy volunteers were recruited for controls of oxidative stress measurements. All psoriasis patients underwent 10 sessions of NB\u2010UVB phototherapy. Measurements were taken at baseline and after 10 sessions of NB\u2010UVB phototherapy. The assessment of carotenoid levels in the skin in vivo was performed by a non\u2010invasive, reflectance spectroscopy\u2010based device. Psoriasis severity was assessed by psoriasis area and severity index (PASI). The dermatology life quality index (DLQI) was evaluated in psoriatic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline carotenoid levels were significantly lower in psoriasis patients in comparison to healthy controls. NB\u2010UVB phototherapy insignificantly diminished carotenoid levels in the skin of psoriasis patients, while clinical improvement both in PASI score and DLQI was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We showed the levels of skin carotenoids in psoriatic patients are lower than in healthy subjects. NB\u2010UVB did not change significantly skin carotenoid levels. Further studies should elucidate the potential effect of antioxidants supplementation during NB\u2010UVB of psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12617","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T03:53:20Z","timestamp":1602042800000},"page":"111-114","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epidermal carotenoid levels in vivo of patients with plaque psoriasis: Effects of narrow\u2010band UVB phototherapy"],"prefix":"10.1111","volume":"37","author":[{"given":"Razvigor","family":"Darlenski","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Trakia University Stara Zagora  Zagora Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radostina","family":"Deliyska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Trakia University Stara Zagora  Zagora Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Tabet","family":"Al\u2010Sadek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Trakia University Stara Zagora  Zagora Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniya","family":"Hristakieva","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Trakia University Stara Zagora  Zagora Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim W.","family":"Fluhr","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 Univer\u00e4tsmedizin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.03.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184347"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2016.1162301"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2304018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14038"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.02.065"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2419096"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2360-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0176-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477355"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365520"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13625"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.6.061230"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules161210491"},{"issue":"5","key":"e_1_2_7_16_1","first-page":"S14","article-title":"The skin in psoriasis: assessment and challenges","volume":"33","author":"Oji V","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201300134"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201100080"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.33594\/000000133"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01976-z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328725"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000162290"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8020302"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/phpp.12617","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T22:47:14Z","timestamp":1693608434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/phpp.12617"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12617","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}