{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:48:03Z","timestamp":1790567283144,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a common disorder manifested by symmetric hyperpigmentation of sun\u2010exposed skin. Although ultraviolet (UV) radiation is a known risk factor of melasma, whether skin sensitivities to UVA and\/or UVB differ between healthy controls and female patients with melasma is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Minimal erythema dose (MED)\u2010UVA and MED\u2010UVB results were compared between female patients with melasma and healthy controls. Additionally, relationships between MED values and Melasma Area and Severity Index (MASI) scores, and skin color were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The melasma and control groups included 142 and 137 subjects, respectively. Compared with healthy control group, our melasma group had lower MED\u2010UVA (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and MED\u2010UVB (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). MASI scores were negatively correlated with MED\u2010UVA and MED\u2010UVB (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Additionally, Skin a* values in melasma\u2010involved skin were negatively correlated with MED\u2010UVA (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Skin b* values in melasma\u2010involved skin were negatively correlated with MED\u2010UVB and MED\u2010UVA (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with melasma exhibit a low MED to both UVA and UVB, rendering them have a predisposition to an increased UV sensitivity. Because of the association between melasma and UV sensitivity, sun exposure should be avoided to alleviate or prevent melasma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12713","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T19:34:42Z","timestamp":1624649682000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chinese women with melasma exhibit a low minimal erythema dose to both UVA and UVB"],"prefix":"10.1111","volume":"38","author":[{"given":"Zixu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Qujing Affiliated Hospital of Kunming Medical University  Qujing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology People's Hospital of Chuxiong Yi Autonomous Prefecture  Chuxiong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690240119022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.046"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143063"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962013000100009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04430.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91271-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12537"},{"key":"e_1_2_8_9_1","first-page":"149","article-title":"Visible light photopatch testing of common photocontactants in female filipino adults with and without melasma: a cross\u2010sectional study","volume":"7","author":"Verallo\u2010Rowell VM","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16206"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07590.x"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"Minimal erythema dose (MED) testing","volume":"75","author":"Heckman CJ","year":"2013","journal-title":"J Vis Exp"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12282"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060015008"},{"key":"e_1_2_8_15_1","first-page":"121","article-title":"Measurement of skin color: practical application and theoretical considerations","volume":"44","author":"Takiwaki H","year":"1998","journal-title":"J Med Invest"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690060057005"},{"key":"e_1_2_8_17_1","first-page":"517","article-title":"Melasma in Latin Americans","volume":"10","author":"Perez M","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30257.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02724.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.02.015"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.12.2379"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1PP05191A"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00391.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13245"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80421"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1PP05271C"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.01.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277170"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12331"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00764.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276983"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13332"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/phpp.12713","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:37:36Z","timestamp":1693222656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/phpp.12713"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12713","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,28]]},"assertion":[{"value":"2021-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}