{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:55:47Z","timestamp":1790146547177,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the clinical efficacy, recurrence rate and safety of 5\u2010aminolevulinic acid\u2013based photodynamic therapy (ALA\u2010PDT) combined with microneedle or CO2 lattice laser (CO2FL), in comparison with intrascar betamethasone injection in the treatment of hypertrophic acne scar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010two patients with hypertrophic acne scars at the mandibular angle were enrolled and assigned to different therapy groups. Sixteen patients were treated with microneedle\u2010assisted incorporation of ALA. Twenty\u2010eight patients underwent CO2FL\u2010assisted incorporation of ALA. Eight patients received standard therapy with intrascar injection of glucocorticoid. Two dermatologists, blinded to the therapy groups, independently evaluated the scars in all patients using the average value of the Vancouver Scar Scale score, which was treated as an integer variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After three rounds of treatment, there was no significant difference in therapeutic effective rate among the microneedle, laser and topical glucocorticoid groups (93.75% vs 100% vs 100%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.855). One out of 16 patients (6.25%) in the microneedle group, no patient (0%) in the laser group and two out of eight patients (25%) in the topical glucocorticoid group had recurrence. The laser group showed a higher rate of adverse effects, which were usually mild and reversible, except for pigmentation. Adverse reactions could be completely subsided within 3\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Either CO2FL or microneedle combined ALA\u2010PDT for hypertrophic scar, as to topical glucocorticoid therapy, showed equivalent clinical effects but lower recurrence rate within 6\u00a0months of follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.12716","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T13:35:41Z","timestamp":1626528941000},"page":"53-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A clinical study of carbon dioxide lattice laser\u2013assisted or microneedle\u2010assisted 5\u2010aminolevulinic acid\u2013based photodynamic therapy for the treatment of hypertrophic acne scars"],"prefix":"10.1111","volume":"38","author":[{"given":"Dongmei","family":"Yan","sequence":"first","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Plastic Surgery of Beijing Hospital National Center for Geriatrics Chinese Academy of Medical Sciences Institute of Geriatrics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Li","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiting","family":"Xia","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Zhang","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yun","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Li","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tian","sequence":"additional","affiliation":[{"name":"General Hospital of Air Force, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.697987"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.07.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06209.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20213"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12180"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2010.07.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00619.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34406.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2059513120932059"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717541003667798"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119673"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.038"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20860"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.03.017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2017.05.007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22120"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12187"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05704.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12099"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23301"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23201"}],"container-title":["Photodermatology, Photoimmunology &amp; 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