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Many subsets of T cells contribute to vitiligo pathogenesis, including resident and circulating memory T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the amounts of CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup>memory T\u2010cell subsets in peripheral blood specimens from vitiligo patients and alterations caused by narrowband ultraviolet B (NB\u2010UVB) phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Circulating CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> central memory T (T<jats:sub>CM<\/jats:sub>) and effector memory T (T<jats:sub>EM<\/jats:sub>) cell frequencies in 33 patients with non\u2010segmental vitiligo and 16 healthy donors were evaluated by flow cytometry. Related chemokine levels were also detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peripheral blood CD4<jats:sup>+<\/jats:sup> T<jats:sub>CM<\/jats:sub> and CD8<jats:sup>+<\/jats:sup> T<jats:sub>CM<\/jats:sub> counts were markedly reduced in vitiligo cases while they were higher in active vitiligo compared with stable vitiligo cases. Circulating CD8<jats:sup>+<\/jats:sup> T<jats:sub>CM<\/jats:sub> frequency in vitiligo was closely related to disease duration. Interestingly, CD4<jats:sup>+<\/jats:sup> T<jats:sub>CM<\/jats:sub> and CD8<jats:sup>+<\/jats:sup> T<jats:sub>CM<\/jats:sub> frequencies, alongside CXCL9 and CXCL10 amounts in peripheral blood of patients with vitiligo, were significantly decreased after NB\u2010UVB phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Decreased frequencies of circulating CD4<jats:sup>+<\/jats:sup> T<jats:sub>CM<\/jats:sub> and CD8<jats:sup>+<\/jats:sup> T<jats:sub>CM<\/jats:sub> by NB\u2010UVB suggest a possible immunosuppressive effect of phototherapy. The chemokines CXCL9 and CXCL10 are the bridge between circulating and skin resident memory T cells. NB\u2010UVB blocks the homing of circulating memory T cells into vitiligo lesions by down\u2010regulating CXCL9 and CXCL10. Targeting the above proteins could provide novel, durable treatment options to cure and prevent flares of this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12719","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T19:52:50Z","timestamp":1626378770000},"page":"76-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Altered circulating memory T cells in vitiligo cases followed NB\u2010UVB therapy"],"prefix":"10.1111","volume":"38","author":[{"given":"Fuquan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dermatology Hangzhou Third People's Hospital Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiukun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hangzhou Third People's Hospital Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehao","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hangzhou Third People's Hospital Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai\u2011e","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hangzhou Third People's Hospital Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.11"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01363.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13879"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.08.038"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18902"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007811"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.4.407"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.040"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.05.014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2019.87448"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017011346"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070517"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.12.021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12667"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14416"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12219"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.021"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900027"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12803"}],"container-title":["Photodermatology, Photoimmunology &amp; 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