{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:22:23Z","timestamp":1783570943896,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>NB\u2010UVB has long been the vitiligo management pillar with capability of achieving the main treatment outcomes; repigmentation and stabilization. Its stabilizing effect in dark skin has been debatable. However, randomized controlled trials regarding NB\u2010UVB ability to control disease activity are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess stabilizing effect of NB\u2010UVB in comparison to systemic corticosteroids, the mainstay in vitiligo stabilization, in skin photo\u2010types (III\u2010V).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicenter, placebo\u2010controlled, randomized, prospective study. Eighty patients with active nonsegmental vitiligo (NSV) (Vitiligo disease activity (VIDA) \u22652) were randomized to either NB\u2010UVB and placebo (NB\u2010placebo) or NB\u2010UVB and dexamethasone oral mini\u2010pulse (OMP) therapy (NB\u2010OMP) for 6\u00a0months. Sixty four patients completed the study, 34 in the NB\u2010OMP group and 30 in the NB\u2010placebo group. Patients were evaluated fortnightly according to presence or absence of symptoms\/signs of activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In spite of earlier control of disease activity observed in the NB\u2010OMP group, it was comparable in both groups by the end of the study period. Disease activity prior to therapy, but not extent, was found to influence control of activity in both groups. Thus, NB\u2010UVB is a safe sole therapeutic tool in vitiligo management. Not only does it efficiently achieve repigmentation, but also it is a comparable stabilizing tool for systemic corticosteroids in spite of slightly delayed control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NB\u2010UVB is the only well\u2010established vitiligo therapy that can be used solely whenever corticosteroids are contraindicated or immune\u2010suppression is unjustified. Nonetheless, its combination with corticosteroids expedites response and improves compliance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12749","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T21:10:04Z","timestamp":1635887404000},"page":"277-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy of narrow band UVB with or without OMP in stabilization of vitiligo activity in skin photo\u2010types (III\u2013V): A double\u2010blind, randomized, placebo\u2010controlled, prospective, multicenter study"],"prefix":"10.1111","volume":"38","author":[{"given":"Samia M.","family":"Esmat","sequence":"first","affiliation":[{"name":"Dermatology Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medhat","family":"El\u2010Mofty","sequence":"additional","affiliation":[{"name":"Dermatology Department Faculty of 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