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A systematic review to support the use of light\u2010 and laser\u2010based treatments for GA is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review by searching Cochrane, MEDLINE, and Embase. Title, abstract, full\u2010text screening, and data extraction were done in duplicate. Quality appraisal was performed using the Joanna Briggs Institute critical appraisal tool for case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one case series met the inclusion criteria, representing a total of 336 patients. Overall, psoralen ultraviolet light A (PUVA) showed the greatest frequency of cases with complete response (59%, <jats:italic>n<\/jats:italic>\u00a0=\u00a077\/131), followed by photodynamic therapy (PDT) (52%, <jats:italic>n<\/jats:italic>\u00a0=\u00a013\/25), ultraviolet light B (UVB)\/narrowband UVB (nbUVB)\/excimer laser (40%, <jats:italic>n<\/jats:italic>\u00a0=\u00a019\/47), UVA1 (31%, <jats:italic>n<\/jats:italic>\u00a0=\u00a027\/86), and lasers (29%, <jats:italic>n<\/jats:italic>\u00a0=\u00a08\/28). Overall across treatment modalities, higher response rates were seen in localized GA compared to generalized GA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The body of evidence for light\u2010 and laser\u2010based treatment of GA is sparse. Our results suggest that PUVA has a high clearance rate for GA but its use may be limited by concerns of carcinogenesis. Although PDT has the second highest clearance rate, adverse effects, small sample sizes, impractical treatment delivery (especially with generalized disease), and long\u2010term concerns of carcinogenesis may limit its use. Although UVB\/nbUVB\/excimer laser appeared slightly less effective than other light therapies, we recommend UVB\/nbUVB\/excimer laser therapy as a first\u2010line treatment for patients with generalized GA given wider availability and a favorable long\u2010term safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12756","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T19:04:40Z","timestamp":1638903880000},"page":"301-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Light\u2010 and laser\u2010based treatments for granuloma annulare: A systematic review"],"prefix":"10.1111","volume":"38","author":[{"given":"Ilya M.","family":"Mukovozov","sequence":"first","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver British Columbia 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