{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:19:37Z","timestamp":1789348777270,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo may be treated with hospital\u2010based phototherapy, but this requires long\u2010term frequent appointments. Self\u2010treatment using home\u2010based phototherapy is a convenient alternative, which may improve adherence and results, but evidence is limited, and so it is not routinely recommended. This systematic review aims to assess the effectiveness and safety of home\u2010based phototherapy for vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Searches were conducted on Medline, Scopus and The Cochrane Library for randomised controlled trials comparing home\u2010based phototherapy with institution\u2010based phototherapy or placebo\/no phototherapy for vitiligo. The primary outcome was treatment effectiveness. CASP criteria were used for quality assessment. Data were synthesised in a meta\u2010analysis where appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three studies (195 participants) were included: two compared home\u2010based with institution\u2010based phototherapy, and one compared home\u2010based phototherapy with placebo. Studies were of mixed quality. Therapy regimes varied across studies. Findings on effectiveness were contradictory across studies with variable rates of repigmentation. There was no significant difference in repigmentation rates between the groups, although adherence to treatment schedules was significantly better in home\u2010based groups. Adverse effects were significantly higher in home\u2010based groups. No long\u2010term data were reported on maintenance of treatment benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although adherence to treatment was significantly better with home\u2010based phototherapy, data were insufficient to form conclusions on effectiveness. Home\u2010based phototherapy had a significantly higher risk of adverse effects, making it difficult to recommend in clinical practice. However, as it offers logistical advantages for patients, its effectiveness alongside additional safety measures should be explored further in large\u2010scale, good\u2010quality RCTs, with standardised outcome measures, including patient\u2010reported outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12766","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T10:28:45Z","timestamp":1640860125000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effectiveness of home\u2010based phototherapy for vitiligo: A\u00a0systematic review of randomised controlled trials"],"prefix":"10.1111","volume":"38","author":[{"given":"Aleena Zehra","family":"Ashraf","sequence":"first","affiliation":[{"name":"School of Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Michael","family":"Azurdia","sequence":"additional","affiliation":[{"name":"Department of Dermatology Liverpool University Hospitals NHS Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart Neil","family":"Cohen","sequence":"additional","affiliation":[{"name":"School of Medicine University of Liverpool  Liverpool UK"},{"name":"Department of Dermatology Liverpool University Hospitals NHS Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506103"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.11"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00226.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084751"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.11.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11197.x"},{"key":"e_1_2_10_10_1","unstructured":"NICE.Management of Vitiligo.2016.https:\/\/cks.nice.org.uk\/vitiligo#!scenario. Accessed 15th September 2021."},{"issue":"7","key":"e_1_2_10_11_1","first-page":"666","article-title":"Phototherapy for vitiligo: a systematic review and meta\u2010analysis","volume":"153","author":"Bae J","year":"2017","journal-title":"J Am Med Assoc Dermatol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5070\/D32TS6S057"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0490-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.12.026"},{"key":"e_1_2_10_15_1","unstructured":"Review Manager (RevMan) [Computer program]. Version\u00a05.3. Copenhagen: The Nordic Cochrane Centre The Cochrane Collaboration 2014."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12495"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-51"},{"key":"e_1_2_10_18_1","unstructured":"ClintonB EleftheriadouV GeelN BenzekriL PandyaAG EzzedineK.Outcome measures for vitiligo.2018. In: S. Gupta M.J. Olsson D. Parsad H.W. Lim N. Geel and A.G. Pandya (eds.). Available from10.1002\/9781118937303.ch7. Accessed 15th September 2021."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12561"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12321"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000047"},{"key":"e_1_2_10_23_1","unstructured":"Public Health Resource Unit.CASP Randomised Controlled Trial Checklist.2013.https:\/\/hhs.hud.ac.uk\/lqsu\/Useful\/critap\/Randomised%20Controlled%20Trials%20Checklist\/CASP\u2010Randomised\u2010Controlled\u2010Trial\u2010Checklist\u201031.05.13.pdf. Accessed 15th September 2021."}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/phpp.12766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:50:29Z","timestamp":1692708629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/phpp.12766"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12766","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,25]]},"assertion":[{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}