{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:05:55Z","timestamp":1789049155654,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:00:00Z","timestamp":1649548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reduced sirtuin 1 (Sirt1) expression in psoriasis was previously reported, and its activation was associated with disease improvement. Narrow\u2010band ultraviolet B (NB\u2010UVB) downregulates several pro\u2010inflammatory cytokines such as interferon\u2010\u03b3 (IFN\u2010\u03b3) and influences keratinocyte differentiation in psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to study the in vivo influence NB\u2010UVB treatment on Sirt1 expression in psoriatic skin in relation to disease improvement and IFN\u2010\u03b3 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six patients with chronic plaque psoriasis were evaluated, and psoriasis area severity index (PASI) was calculated. Skin biopsies were taken from lesional skin of the patients before and after 3 months of treatment with NB\u2010UVB and from 26 controls, where the distribution and immunohistochemistry (IHC) scores of Sirt1 and IFN\u2010\u03b3 were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3 months of treatment, Sirt1 distribution and epidermal IHC score were significantly higher, whereas Sirt1 dermal IHC score and IFN\u2010\u03b3 distribution, epidermal and dermal IHC scores were significantly lower than the pre\u2010treatment values. Before and after 3 months of NB\u2010UVB therapy, PASI showed a significant negative correlation with Sirt1 distribution and epidermal IHC score; and a significant positive correlation with interferon\u2010\u03b3 distribution and epidermal IHC score. Moreover, Sirt1 distributions were negatively correlated with the corresponding interferon\u2010\u03b3 distributions.<\/jats:p><jats:p>Conclusions<\/jats:p><jats:p>The detected upregulation of epidermal Sirt1 following NB\u2010UVB therapy possibly represents another mechanism by which NB\u2010UVB can act in psoriasis and also highlights the role of Sirt1 upregulation in psoriasis treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12790","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:18:13Z","timestamp":1648646293000},"page":"555-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of narrow\u2010band ultraviolet B therapy on sirtuin 1 expression in lesional skin of patients with chronic plaque psoriasis: Relation to clinical improvement and interferon\u2010\u03b3 expression"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-2778","authenticated-orcid":false,"given":"Amira Abulfotooh","family":"Eid","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Gaber","family":"Aly","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa Abd Elkarim","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama\u00a0Ahmed","family":"Sorour","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.458"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.2.155"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.03.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00657-10"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"157","article-title":"Abnormal expression of SIRTs in psoriasis: decreased expression of SIRT 1\u20105 and increased expression of SIRT 6 and 7","volume":"44","author":"Fan X","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-172288"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30279"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142081"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-007-9592-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0420"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2000.160502.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.054"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.05.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.042"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.01.033"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/75.6.816"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096801"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-016-1482-y"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.179"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.82"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.53"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00246.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00453.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150175"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14048456"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061572"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.05.017"}],"container-title":["Photodermatology, Photoimmunology &amp; 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