{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:06:20Z","timestamp":1763535980857,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Caveolin\u20101 (Cav\u20101) is a significant structural and regulatory constituent of cell membranes that has been implicated in cell kinetics and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess Cav\u20101 expression in psoriasis before and after phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Thirty psoriasis cases and 30 healthy controls were recruited. Cases were managed with narrow band\u2010ultraviolet B (NB\u2010UVB) phototherapy at frequency three times per week for 12\u2009weeks. From every case, two biopsy specimens were gained from psoriatic lesions (pre and post phototherapy), in addition to one from apparently normal skin of psoriasis cases. Regarding the control group, one biopsy was taken from a matched site. All were studied for Cav\u20101 antibody immuno\u2010expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant decrease in Cav\u20101 expression in psoriatic lesions compared to both the apparently normal skin of psoriasis patients and standard control skin of healthy individuals. After NB\u2010UVB phototherapy, significant upregulation of Cav\u20101 immunostaining score was observed in previously psoriatic skin when compared to that before treatment. In addition, there were significant negative correlations between Cav\u20101 immunostaining score and the clinical scores of psoriasis severity including; the erythema, scaling, and induration (ESI) score and the patient psoriasis area and severity index (PASI) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Induction of Cav\u20101 expression may be a likely pathway for the effectiveness of NB\u2010UVB in psoriasis. Cav\u20101 may be a useful marker for evaluation of psoriasis severity, disease progression, and therapeutic efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12822","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T07:36:41Z","timestamp":1658389001000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of <scp>NB\u2010UVB<\/scp> phototherapy on Caveolin\u20101 expression in chronic plaque psoriasis"],"prefix":"10.1111","volume":"39","author":[{"given":"Marwa B.","family":"Elsherbeni","sequence":"first","affiliation":[{"name":"Dermatology Department Kafr El Sheikh Hospital of Dermatology and Leprosy  Kafr El Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-5365","authenticated-orcid":false,"given":"Yomna Mazid El\u2010Hamd","family":"Neinaa","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"},{"name":"Dermatopathology Unite, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed\u00a0M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagwa M.","family":"Elwan","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"},{"name":"Dermatopathology Unite, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2360-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2009.12.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2005.08.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-019-0034-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.8.2229"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.328"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.131374"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000513"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.249"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2018.06.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_46_17"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083509"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0176-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/69804"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.05.023"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100959"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2021.4015"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/618269"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.166"},{"issue":"4","key":"e_1_2_9_22_1","first-page":"633","article-title":"Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes","volume":"15","author":"Wang Q","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2012.11124"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010060"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7454031"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21970"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36767-5"}],"container-title":["Photodermatology, Photoimmunology &amp; 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