{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:27:18Z","timestamp":1760218038937},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have reported postoperative relapse of condyloma acuminatum (CA) after 5\u2010aminolevulinic acid photodynamic therapy (ALA\u2010PDT) in human immunodeficiency virus (HIV) positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of HIV\u2010positive CA patients treated with ALA\u2010PDT from October 2018 to December 2019 were analyzed retrospectively. Univariate and multivariate Cox regression was used to analyze the variables related to postoperative recurrence. Pearson correlation test was employed to analyze the correlation between CD4<jats:sup>+<\/jats:sup> T cell count and postoperative recurrence rate. Kaplan\u2013Meier method was used to compare the CA recurrence after ALA\u2010PDT in low CD4 group and high CD4 group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 38 HIV\u2010positive patients with CA were included in the study. Among them, 26 patients experienced CA recurrence within 6\u2009months, and the recurrence rate was 68.4%. CD4<jats:sup>+<\/jats:sup> T cell count was 187.0 (79.0\u2013596.0) cells\/\u03bcl in relapsed patients and 406.0 (89.0\u2013612.0) cells\/\u03bcl in non\u2010relapsed patients, showing a statistically significant difference (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). Pearson correlation coefficient analysis revealed a negative correlation between CD4<jats:sup>+<\/jats:sup> T cell count and postoperative recurrence rate (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.443). Univariate regression analysis showed that CD4<jats:sup>+<\/jats:sup> T cell count was correlated with postoperative recurrence, hazard ratio (HR) was 0.99 [95% Confidence interval (CI)\u00a0=\u00a00.99\u20131.0, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012]. Multivariate Cox regression analysis showed that with the low CD4<jats:sup>+<\/jats:sup> T cell count as the reference, the high CD4<jats:sup>+<\/jats:sup> T cell count was negatively correlated with postoperative recurrence (HR\u00a0=\u00a00.09, 95% CI 0.01\u20130.87, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peripheral blood CD4<jats:sup>+<\/jats:sup> T cell count can predict the CA recurrence rate after ALA\u2010PDT in HIV\u2010positive patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12832","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T09:18:35Z","timestamp":1662110315000},"page":"246-255","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peripheral blood <scp>CD4<\/scp><sup>+<\/sup> T cell count predicts recurrence of condyloma acuminatum after photodynamic therapy in 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