{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:44:42Z","timestamp":1745534682622},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ultraviolet radiation can aggravate facial erythema in atopic dermatitis (AD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the photobiological testing results of Chinese AD patients with refractory facial erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of 82\u2009AD patients with refractory facial erythema who visited our department during 2004\u20132021. All of them completed phototesting and photopatch testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>82 patients were enrolled in the study, and 53 (64.6%) were between 18 and 30\u2009years old. 51.2% (42\/82) had positive phototesting results and were considered photosensitive AD (PhAD) patients. One\u2010third of them were both allergic to ultraviolet A and ultraviolet B. 65.9% (54\/82) suffered from photoallergic contact dermatitis. Chlorpromazine (50.7%), potassium dichromate (13.2%), and thimerosal (11.8%) were the top three common photoallergens. Overall, 86.3% of AD patients with refractory facial erythema had direct photoallergy or photocontact allergy. PhAD patients had fewer allergic comorbidities than the other group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007). More non\u2010PhAD patients (55.0%) suffered from AD at 2\u201314\u2009years old (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photosensitivity contributes a lot to the facial lesions of AD patients, especially in their 20s. 86.3% of these patients had direct photoallergy or photocontact allergy. Therefore, AD patients with facial erythema should undergo phototesting and photopatch testing routinely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12836","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T16:13:57Z","timestamp":1663085637000},"page":"318-324","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Photosensitivity is an important cause of refractory facial erythema in atopic dermatitis: A retrospective study of 82 Chinese patients"],"prefix":"10.1111","volume":"39","author":[{"given":"Haiqing","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Allergy and Immunology Huashan Hospital affiliated to Fudan University  Shanghai China"},{"name":"Department of Dermatology Huashan Hospital affiliated to Fudan University  Shanghai 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Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology Huashan Hospital affiliated to Fudan University  Shanghai China"},{"name":"Department of Dermatology Huashan Hospital affiliated to Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology Huashan Hospital affiliated to Fudan University  Shanghai China"},{"name":"Department of Dermatology Huashan Hospital affiliated to Fudan University  Shanghai 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