{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:49:50Z","timestamp":1792082990146,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigates the dermatological as well as the esthetic potential of light\u2010emitting diodes (LEDs) by performing a systematic review and meta\u2010analysis. From the electronic databases, 554 articles were assessed; however, only 31 studies were selected after manually screening and eliminating unnecessary studies. The potential effectiveness of LEDs for skin therapies was assessed by evaluating the standardized mean differences (SMDs) and funnel plots of this meta\u2010analysis. It was discovered that both red and blue LED lights play an important role in the treatment of acne vulgaris with an overall statistically significant SMD of \u22122.42 [\u22122.64, \u22122.15] and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a017%\u2009&lt;\u200950%. Additionally, other LEDs (e.g., yellow LEDs and near\u2010infrared devices) showed outstanding levels of effectiveness, not only in reducing the lesions of herpes simplex and psoriasis but also in improved skin rejuvenation with highly consistent analytical results (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00% and 33%, respectively). However, the analysis of LED\u2010based skin wound healing and atopic dermatitis treatments exhibited heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a085% and 90%) due to the lack of unpublished articles. In conclusion, it is suggested that LEDs are useful for dermatology and could be potential candidates for future cosmetic applications.<\/jats:p>","DOI":"10.1111\/phpp.12841","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T07:41:40Z","timestamp":1667202100000},"page":"303-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Utilization of light\u2010emitting diodes for skin therapy: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"39","author":[{"given":"Le Thi Nhu","family":"Ngoc","sequence":"first","affiliation":[{"name":"Department of Industrial and Environmental Engineering, Graduate School of Environment Gachon University  Seongnam\u2010Si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Beauty Design Management Han\u2010sung University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of BioNano Technology Gachon University  Seongnam\u2010Si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.08.003"},{"key":"e_1_2_10_3_1","first-page":"36","article-title":"Light\u2010emitting diodes: a brief review and clinical experience","volume":"8","author":"Opel DR","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2599-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.630081"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000981"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20455"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.2.163"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR06444J"},{"key":"e_1_2_10_10_1","first-page":"41","volume-title":"Low\u2010Level Laser (Light) Therapy (LLLT) in Skin: Stimulating, Healing, Restoring. In: Seminars in Cutaneous Medicine and Surgery","author":"Avci P","year":"2013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22791"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2016.2561201"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40580-019-0200-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.04.033"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102221"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30053.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.110755"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002350"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41528-019-0058-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11362-2"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051487"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_10_26_1","first-page":"1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Peterson J","year":"2011"},{"key":"e_1_2_10_27_1","first-page":"25","article-title":"Efficacy and tolerability of a combined 445nm and 630nm over\u2010the\u2010counter light therapy mask with and without topical salicylic acid versus topical benzoyl peroxide for the treatment of mild\u2010to\u2010moderate acne vulgaris","volume":"9","author":"Nestor MS","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2015.1007064"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12098"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12186"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1793545811001241"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962009000500003"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33258.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32221.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12069"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02191.x"},{"key":"e_1_2_10_37_1","first-page":"115","article-title":"A randomized, placebo\u2010controlled, single\u2010blinded, split\u2010faced clinical trial evaluating the efficacy and safety of KLOX\u2010001 gel formulation with KLOX light\u2010emitting diode light on facial rejuvenation","volume":"9","author":"Nikolis A","year":"2016","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/01676830903043959"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170701400085"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2007.04.008"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-005-0330-5"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002195"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1666-5"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1520-4"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430495"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04039.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333364"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448000"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01137.x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00358.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170701213439"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mla.2006.06.001"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.7841\/ksbbj.2018.33.2.57"},{"key":"e_1_2_10_54_1","first-page":"605","article-title":"Anti\u2010inflammatory properties of narrow\u2010band blue light","volume":"5","author":"Shnitkind E","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7AN01866E"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2019.17085"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.186"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09326.x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00586.x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(98)00219-X"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2017.15079"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2017.10.051"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0371-x"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2019.01.006"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/phpp.12841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T07:54:29Z","timestamp":1692345269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/phpp.12841"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12841","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]},"assertion":[{"value":"2022-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}