{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:40:59Z","timestamp":1780065659738,"version":"3.54.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photochemotherapy with bathwater delivery of psoralens plus UVA exposures (bath\u2010PUVA) is mainly used for those psoriatic patients who are not responsive to narrowband (NB)\u2010UVB phototherapy and oral\u2010PUVA therapy and belong to two categories (1) patients with psoriasis without systemic comorbidities who do not need long\u2010term continuous treatment and (2) patients who have contraindications to immunosuppressive drugs and oral\u2010PUVA or refuse systemic drugs, including oral ingestion of psoralens, for personal reasons. However, it is not known how many patients belong to the second group and how much bath\u2010PUVA is effective and safe for them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have reviewed the treatment results of a cohort of 120 patients with clinical indication to bath\u2010PUVA for the above\u2010mentioned reasons between 2010 and 2019. These patients were selected among 2640 patients with moderate and severe psoriasis who were treated in our department in the same time interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six patients completed at least one treatment cycle with bath\u2010PUVA. A per\u2010protocol analysis showed that average number of treatment sessions was 21.3\u2009\u00b1\u20099.0 and the cumulative UVA dose was 80.4\u2009\u00b1\u200960.0\u00a0J\/cm<jats:sup>2<\/jats:sup>. The average PASI scores decreased from 20.8\u2009\u00b1\u20097.9 to 5.1\u2009\u00b1\u20095.4 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Sixty\u2010seven (69.7%) patients achieved at least a 75% improvement (PASI<jats:sub>75<\/jats:sub>) and, of them, 38 (39.6%) had an improvement greater than 90% (PASI<jats:sub>90<\/jats:sub>). Adverse effects were mild and transitory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings demonstrate that bath\u2010PUVA is still a valuable treatment option for a high number of patients who reject systemic treatments or have contraindications to systemic immune\u2010modifying drugs and have had a limited or no improvement with NB\u2010UVB phototherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12846","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T13:50:21Z","timestamp":1668779421000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bath\u2010PUVA still represents a valuable treatment option for the subsets of psoriatic patients who are not eligible to or rejecting systemic treatments and are not responsive to NB\u2010UVB phototherapy"],"prefix":"10.1111","volume":"39","author":[{"given":"PierGiacomo","family":"Calzavara\u2010Pinton","sequence":"first","affiliation":[{"name":"Dermatology Department, ASST Spedali Civili di Brescia University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariachiara","family":"Arisi","sequence":"additional","affiliation":[{"name":"Dermatology Department, ASST Spedali Civili di Brescia University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tonon","sequence":"additional","affiliation":[{"name":"Dermatology Department, ASST Spedali Civili di Brescia University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Calzavara\u2010Pinton","sequence":"additional","affiliation":[{"name":"Dermatology Department, ASST Spedali Civili di Brescia University of Brescia  Brescia 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