{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:30:37Z","timestamp":1782883837974,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (MF) is the most common cutaneous T\u2010cell lymphoma. Skin\u2010directed therapies, including phototherapy, are the first\u2010line treatment modalities. Psoralen plus ultraviolet A light photochemotherapy (PUVA) is quite effective in controlling the disease; however, long\u2010term adverse effects, particularly carcinogenesis, are the cons of this treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>There are various studies on the negative impact of PUVA on skin cancer in patients with autoimmune skin diseases. The data on the long\u2010term effects of phototherapy on MF patients are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All MF cases that received PUVA alone or combined with other treatments at a single tertiary center were analyzed. This study compared the development of non\u2010melanoma skin cancers, melanoma, and solid organ tumors in MF patients with at least 5\u2010year follow\u2010up data with age\u2010 and sex\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 104 patients were included in the study. Ninety\u2010two malignancies were detected in 16 (15.4%) patients, and six developed multiple malignancies. Skin cancers consisted of 56 basal cell carcinomas, 16 Bowen's disease, four squamous cell carcinomas, three melanomas, two basosquamous cell carcinomas, one Kaposi sarcoma, and one keratoacanthoma were found in nine (8.7%) patients. Eight patients developed three solid cancers and six lymphomas. The risk of developing skin cancer was associated with the total number of PUVA sessions (&lt;250 vs \u2265250 sessions; hazard ratio (HR) 4.44, 95% confidence interval (CI) 1.033\u201319.068; <jats:italic>p<\/jats:italic>\u2009=\u2009.045). 9 (13.2%) of 68 patients who had follow\u2010ups for at least 5\u2009years developed skin cancer. Compared to an age\u2010 and sex\u2010matched cohort, the prevalence of new skin cancer was considerably greater (<jats:italic>p<\/jats:italic>\u2009=\u2009.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with MF are predisposed to develop secondary malignancies, and continual exposure to PUVA may potentiate this risk. Annual digital dermoscopic follow\u2010up in MF patients treated with UVA is advised for early diagnosis and treatment of secondary cutaneous malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12872","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:24:07Z","timestamp":1679898247000},"page":"428-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk of skin cancers in mycosis fungoides patients receiving <scp>PUVA<\/scp> therapy: A real\u2010life experience from a single tertiary center"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-0585","authenticated-orcid":false,"given":"Pelin Ertop","family":"Do\u011fan","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Dermatology Department Ankara University  06230 Ankara Turkey"},{"name":"Faculty of Medicine, Dermatology Department Zonguldak Bulent Ecevit University  67600 Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-1666","authenticated-orcid":false,"given":"Beng\u00fc Nisa","family":"Akay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dermatology Department Ankara University  06230 Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6561-196X","authenticated-orcid":false,"given":"Se\u00e7il","family":"Vural","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dermatology Department Ankara University  06230 Ankara Turkey"},{"name":"Department of Dermatology and Venereology Ko\u00e7 University School of Medicine  34010 Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7391-0000","authenticated-orcid":false,"given":"Canan","family":"Ar\u0131","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dermatology Department Ankara University  06230 Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-5212","authenticated-orcid":false,"given":"Tu\u011f\u00e7e Ert\u00fcrk","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dermatology Department Ankara University  06230 Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"\u015eanl\u0131","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dermatology Department Ankara University  06230 Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2584"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.23736\/s0392-0488.17.05737-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1996.tb05657.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.05.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70021-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00898.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04520.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1033"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03389.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02928.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(94)70017-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90241-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1133882"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.04.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114576"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4274\/tdd.2413"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13121"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0337-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.14"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002072"}],"container-title":["Photodermatology, Photoimmunology &amp; 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