{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:51:38Z","timestamp":1785840698320,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemoporfin\u2010mediated photodynamic therapy (HMME\u2010PDT) is currently considered one of the most promising therapies for port\u2010wine stain (PWS). However, the efficacy of this is very variable and needs further studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME\u2010PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The efficacy of HMME\u2010PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1\/2\/last session (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Ordinal logistic regression analysis confirmed the above\u2010mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our studies demonstrated that HMME\u2010PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin\u2010PDT, while multiple HMME\u2010PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12874","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T10:10:27Z","timestamp":1681121427000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of related factors affecting hemoporfin\u2010mediated photodynamic therapy for port\u2010wine stain: A retrospective study"],"prefix":"10.1111","volume":"39","author":[{"given":"Jiajie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Anhui Medical University  Hefei Anhui 230022 China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education  Hefei Anhui 230022 China"},{"name":"Inflammation and Immune\u2010Mediated Diseases 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