{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:48:00Z","timestamp":1790023680940,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Xeroderma pigmentosum (XP) is a rare autosomal\u2010recessive genodermatosis resulting from a DNA\u2010repair defect syndrome. The purpose was to evaluate the prevention on new malignant lesions in patients taking a supplement with Fernblock\u00ae (<jats:italic>Polypodium leucotomos<\/jats:italic> extract [PLE]) and secondarily correlation with the photoprotective behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, single\u2010center and open cohort study was conducted over a 12\u2010month period. The study was performed in Morocco. Optimal photoprotection behavior was recommended. Patients were instructed to take one capsule containing 480\u2009mg of Fernblock\u00ae and 5 mcg vitamin D and to apply sunscreen with a SPF50+ and Fernblock\u00ae every 2\u2009h during sun exposure. The demographic, clinical, and dermatoscopic patient data were collected at baseline (T0) and following visits at 3\u2009months (T3), 6\u2009months (T6), and 12\u2009months (T12) when it was assessed: Investigator Global Assessment (IGA), Patient\/Guardian Global Assessment (PGA), Patient\/Guardian Satisfaction Questionnaire, and Photographic and Adverse Events Registration. Pertinent statistical study was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients completed the study. Eleven patients (61%) finished the study without new lesions. Seven patients developed new lesions by the end of the study. Among them, only 30% showed an ideal photoprotective behavior. The lack of an optimal photoprotective behavior increased the probability of developing lesions by 2.5 times with 95% confidence interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study, more than 60% of patients taking a supplement with Fernblock\u00ae did not develop new lesions, and furthermore, we detected that patients following almost ideal photoprotection were 2.5 times less likely to develop NMSC lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12904","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:51:13Z","timestamp":1692424273000},"page":"607-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the effectiveness and safety of combined oral and topical photoprotection with a standardized extract of <i>Polypodium leucotomos<\/i> (Fernblock\u00ae) in a Moroccan population with xeroderma pigmentosum"],"prefix":"10.1111","volume":"39","author":[{"given":"M.","family":"El\u00a0Mansouri","sequence":"first","affiliation":[{"name":"Department of dermatology University of Hassan II Casablanca, Ibn Rochd University Hospital  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Essaddouki","sequence":"additional","affiliation":[{"name":"Department of dermatology University of Hassan II Casablanca, Ibn Rochd University Hospital  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mouradi","sequence":"additional","affiliation":[{"name":"Department of dermatology University of Hassan II Casablanca, Ibn Rochd University Hospital  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Oukerroum","sequence":"additional","affiliation":[{"name":"Department of maxillofacial surgery University of Hassan II Casablanca, Ibn Rochd University Hospital  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Z.","family":"El\u00a0Fatoiki","sequence":"additional","affiliation":[{"name":"Department of dermatology University of Hassan II Casablanca, Ibn Rochd University Hospital  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Truchuelo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Vithas Madrid Arturo Soria Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Vitale","sequence":"additional","affiliation":[{"name":"Medical Department Cantabria labs  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Medicine and Medical Specialties Department University of Alcal\u00e1 de Henares  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chiheb","sequence":"additional","affiliation":[{"name":"Department of dermatology University of Hassan II Casablanca, Ibn Rochd University Hospital  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0707-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2017.09.420"},{"key":"e_1_2_8_4_1","unstructured":"El MenouarH.Xeroderma pigmentosum: cartographie et profil \u00e9pid\u00e9mio\u2010 clinique exp\u00e9rience du service de dermatologie CHU Ibn rochd. 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