{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:16:39Z","timestamp":1757312199362,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ablative carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser is still a cornerstone in the management of xanthelasma. However, post\u2010laser complications such as post\u2010inflammatory hyperpigmentation or scarring have to be considered. Heparin sodium was recently suggested as an effective therapeutic modality for xanthelasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this work was to compare the therapeutic value of ablative CO<jats:sub>2<\/jats:sub> laser versus intradermal heparin sodium in xanthelasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was piloted on 30 xanthelasma patients, whose lesions were randomly categorized into two groups. Group A was managed with CO<jats:sub>2<\/jats:sub> laser ablation (2 sessions scheduled every 4\u2009weeks), whereas Group B was managed with intradermal heparin sodium injections (10 sessions scheduled every week). Pre\u2010 and post\u2010treatments evaluations were done both clinically and dermoscopically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant reduction of xanthelasma lesions was reported in response to both therapeutic interventions. However, the ablative CO<jats:sub>2<\/jats:sub> laser was more significantly effective than intradermal heparin sodium. Interestingly, intradermal injection of heparin sodium was nearly as effective as ablative CO<jats:sub>2<\/jats:sub> laser in early (&lt;2\u2009years duration) grade I and II xanthelasma, with a lower incidence of post\u2010therapy side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intradermal injection of heparin sodium could be suggested as a safe and cost\u2010effective therapeutic technique for early mild grade I and II xanthelasma. Moreover, it could be recommended as a pre\u2010operative management of grade III and IV xanthelasma to reduce the lesions to be easily ablated with CO<jats:sub>2<\/jats:sub> laser.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12915","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T06:10:28Z","timestamp":1696054228000},"page":"648-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and dermoscopic assessment of ablative carbon dioxide laser versus intradermal heparin sodium in xanthelasma"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-5365","authenticated-orcid":false,"given":"Yomna Mazid El\u2010Hamd","family":"Neinaa","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassant Sherif El\u2010Sayed","family":"Awara","sequence":"additional","affiliation":[{"name":"Dermatology Department Zaitoun Specialized Hospital  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama El\u2010Said","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naeim Mohammed","family":"Abd\u00a0El\u2010Naby","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S130116"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164607"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwac070"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15353"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_56_17"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13534"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2018.4580"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.1999.10"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1955.01540260030006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12723"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16509"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2013.40.4.380"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.234"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/JEWD.JEWD_38_19"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12636"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31825e697c"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001310"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.082"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003078"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555576107110"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.155084"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000172"},{"key":"e_1_2_10_24_1","first-page":"AB170","article-title":"A comparative study: 30% trichloroacetic acid versus ultrapulse CO2 laser in treatment of xanthelasma palpebrarum","volume":"64","author":"Goel K","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1775776"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16475"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12148"}],"container-title":["Photodermatology, Photoimmunology &amp; 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