{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:33:34Z","timestamp":1753878814626,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Favipiravir is an antiviral agent, recently used for COVID\u201019 infections. Several reports associate favipiravir intake with Wood's lamp fluorescence of hair, nails, and sclera. The present study was designed to elucidate the positivity rates, and sites of favipiravir\u2010related fluorescence and to unravel the site\u2010specific changes in fluorescence positivity rates by a function of time past exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised 50 patients and 50 control individuals. All patients in the patient group had received a full dose of favipiravir for COVID\u201019 infection. Fifty volunteers served as the control group. Wood's lamp examination was performed in a completely darkened room, and the positivity rate, extent, pattern, and distribution of fluorescence were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Wood's light revealed fluorescence of the fingernails, toenails, sclera, and hair in 35 (70%), 35 (70%), 22 (44%), and 8 (16%) patients, respectively. No control individual tested positive by Wood's lamp. Statistical analysis revealed significant differences between patient and control groups in terms of Wood's light luminescence in the fingernails (<jats:italic>p<\/jats:italic>\u2009=\u2009.000), toenails (<jats:italic>p<\/jats:italic>\u2009=\u2009.000), sclera (<jats:italic>p<\/jats:italic>\u2009=\u2009.000) and hair (<jats:italic>p<\/jats:italic>\u2009=\u2009.003). Although fingernail, toenail, and hair fluorescence positivity rates declined or ceased at or after 91\u2009days of favipiravir exposure, ocular fluorescence positivity rates were prolonged up to 188\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings confirm that favipiravir may produce fluorescence of nails, sclera, and hair, detectable by Wood's light starting from the initial month and peaking at second\u2010 and third months following exposure to the medication. Although nail and hair fluorescence tend to abate after 3\u2009months, ocular fluorescence may persist even longer than 6\u2009months after cessation of the medication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12919","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T09:45:05Z","timestamp":1698313505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Luminescence of favipiravir in skin appendages and sclera. A\u00a0controlled study and literature review"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-3075","authenticated-orcid":false,"given":"Deniz","family":"Demircio\u011flu","sequence":"first","affiliation":[{"name":"Department of Dermatology Ac\u0131badem Mehmet Ali Ayd\u0131nlar University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-9720","authenticated-orcid":false,"given":"Emel \u00d6zt\u00fcrk","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ac\u0131badem Mehmet Ali Ayd\u0131nlar University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00175-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.08.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.04.035"},{"key":"e_1_2_9_5_1","first-page":"35","article-title":"Fluorescence in the sclera, nails, and teeth secondary to Favipiravir use for COVID\u201019 infections","volume":"15","author":"Durmaz E\u00d6","year":"2022","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_6_1","unstructured":"Newsbeezer.The truth was spread as an \u201calternative to the corona test\u201d. 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