{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:31:47Z","timestamp":1791901907541,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100019266","name":"Korea Medical Device Development Fund","doi-asserted-by":"publisher","award":["202014X4502"],"award-info":[{"award-number":["202014X4502"]}],"id":[{"id":"10.13039\/100019266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea is a chronic skin disorder characterised by abnormal neurovasculature and inflammation in the central region of the face. The efficacy of pulsed\u2010dye laser and intense pulsed light treatments for rosacea have been demonstrated in several clinical trials. However, there is currently no research on the efficacy of long\u2010pulsed alexandrite laser (LPAL) therapy alone for rosacea\u2010related facial redness and its effect on skin microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of LPAL therapy on facial redness in rosacea and assess changes in skin microbiota composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects with rosacea (<jats:italic>n<\/jats:italic>\u2009=\u200921, mean age: 39.2\u2009\u00b1\u200911.3\u2009years) were recruited from two medical institutions and received monthly LPAL treatments (Clarity II\u2122, Lutronic Corp.) for 3\u2009months. At each visit, clinical photographs were taken, and erythema was measured using a spectrometer. At the initial and final visits, the Dermatology Life Quality Index (DLQI) and Skin Sensitivity Questionnaire (SSQ) were evaluated. Skin swabs were obtained at the initial and final visit, and facial microbiome composition was analysed using 16S rRNA amplicon sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After three LPAL treatment sessions, the average facial erythema index, measured using Mexameter\u00ae decreased significantly from 360.0\u2009\u00b1\u200996.7 at baseline to 312.0\u2009\u00b1\u200994.5 at the final visit (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The DLQI and SSQ showed significant improvement of symptoms. Skin microbiome diversity and relative abundance were altered significantly, particularly in the genera <jats:italic>Clostridium, Lawsonella, Bacteroides<\/jats:italic>, and <jats:italic>Lactobacillus<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LPAL therapy alone showed favourable efficacy for the treatment of facial redness in rosacea, with some impacts on the skin microbiota composition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12921","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T01:23:25Z","timestamp":1698456205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effects of long\u2010pulsed alexandrite laser therapy on facial redness and skin microbiota compositions in rosacea: A\u00a0prospective, multicentre, single\u2010arm clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Sujin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunwoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seol Hwa","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jeong","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Ju","family":"Ahn","sequence":"additional","affiliation":[{"name":"HuNBiome Co., Ltd. R&amp;D Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Dermatology Yongin Severance Hospital  Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.077"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.161870"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.08.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-020-00297-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00460-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19315"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.630"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071487"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2859"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.03.1501"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010185"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14349"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03200-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23605"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1300"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.048"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01327.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2021.21"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12251"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14098"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111756"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23087"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41322-x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.864198"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:27:10Z","timestamp":1706614030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/phpp.12921"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12921","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,2]]},"assertion":[{"value":"2023-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"phpp.12921"}}