{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:44:05Z","timestamp":1776800645796,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Narrowband ultraviolet B (NB\u2010UVB) phototherapy is the cornerstone of vitiligo treatment. Its combination with other treatments usually yields a better response. Latanoprost, a prostaglandin F2\u03b1 analog, and autologous platelet\u2010rich plasma (PRP) have been reported to be effective for vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of NB\u2010UVB combined with intralesional latanoprost or PRP for stable nonsegmental vitiligo (NSV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients with stable NSV were recruited and randomly allocated to two equal groups. NB\u2010UVB phototherapy was administered twice a week for all patients. Additionally, group A received intralesional latanoprost injections once weekly, while group B received intralesional autologous PRP injections every 2\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 24\u2009weeks, excellent repigmentation response was observed in 26.7% and 13.3% of patients in the latanoprost\/NB\u2010UVB and PRP\/NB\u2010UVB groups, respectively, with no significant difference in degrees of repigmentation between the two groups. However, the Vitiligo Extent Score for a Target Area (VESTA) score was significantly higher in the latanoprost\/NB\u2010UVB group (<jats:italic>p<\/jats:italic>\u2009=\u2009.032). Moreover, lesions located on nonacral skin responded significantly better than those on acral skin. Only erythema was significantly higher in the PRP\/NB\u2010UVB group, while the recurrence of depigmentation was significantly higher in the latanoprost\/NB\u2010UVB group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both latanoprost and PRP have the potential to be effective add\u2010on therapies to NB\u2010UVB phototherapy for stable NSV, with latanoprost resulting in a greater repigmentation response and PRP producing a more stable response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12929","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:14:01Z","timestamp":1700604841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Narrowband ultraviolet B phototherapy combined with intralesional injection of either latanoprost or platelet\u2010rich plasma for stable nonsegmental vitiligo"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-9672","authenticated-orcid":false,"given":"Manal","family":"Fawzy","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Al\u2010Mokadem","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabrokah","family":"Alshereef","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.048"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02278.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.11.008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1658860"},{"issue":"6","key":"e_1_2_11_6_1","first-page":"14139","article-title":"The effect of narrow\u2010band ultraviolet B rays alone versus its combination with intralesional injection of latanoprost in the treatment of vitiligo","volume":"25","author":"Ibrahim HG","year":"2021","journal-title":"Ann Romanian Soc Cell Biol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12631"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12383"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14813"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12363"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01612.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08923.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13175"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.059"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2009.04.007"},{"key":"e_1_2_11_16_1","unstructured":"LimHK ShinMK LeeMH.Clinical application of platelet\u2010rich plasma in vitiligo: a pilot study.Official 1st International Pigment Cell Conference.2011."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.18535\/jmscr\/v7i3.57"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03195-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12194"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S178817"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13103"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12397"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.041"},{"issue":"5","key":"e_1_2_11_24_1","first-page":"87","article-title":"Treatment of periorbital hyperpigmentation using platelet\u2010rich plasma injections","volume":"3","author":"Al\u2010Shami SH","year":"2014","journal-title":"Am J Dermatol Venereol"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22260"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12730"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00270.x"},{"issue":"1","key":"e_1_2_11_28_1","first-page":"32","article-title":"Platelet\u2010rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase\u20101 in human skin fibroblasts","volume":"29","author":"Cho JW","year":"2012","journal-title":"Int J Mol Med"},{"issue":"5","key":"e_1_2_11_29_1","first-page":"466","article-title":"Face and neck revitalization with platelet\u2010rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients","volume":"9","author":"Redaelli A","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_30_1","first-page":"79","article-title":"Vitiligo surgery: its evolution as a definite treatment in the stable vitiligo","volume":"145","author":"Holla AP","year":"2010","journal-title":"G Ital Dermatol Venereol"}],"container-title":["Photodermatology, Photoimmunology &amp; 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