{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:28:50Z","timestamp":1781011730918,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (MF) is a chronic, highly recurrent cutaneous T\u2010cell lymphoma, whose pathogenesis has not yet been fully elucidated. Interleukin\u201015 was previously highlighted as a viability factor for cutaneous T\u2010cell lymphoma with previous studies shedding light on its role in pathogenesis of MF and its plausibility as a potential therapeutic target.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was conducted to evaluate serum and tissue expression of IL\u201015 and IL\u201015R\u03b1 in early cases of MF (IA, IB, IIA) at baseline and following phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fourteen early MF cases were recruited. Samples were withdrawn prior to starting phototherapy treatment and following near complete clearance of the biopsied lesion or after a maximum of 36 sessions of phototherapy. Samples were assessed for change in expression of IL\u201015 and IL\u201015 R\u03b1 levels following treatment, whose levels were compared to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum and tissue levels of IL\u201015 and IL\u201015R\u03b1 in early MF cases were significantly higher at baseline than their levels following phototherapy treatment and higher than healthy controls. However, they dropped significantly following treatment with no statistical difference between treated cases and controls, apart from serum IL\u201015R\u03b1 that remained significantly elevated than controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interleukin\u201015 and its receptor alpha appear to contribute to the pathogenesis of MF, being significantly elevated than healthy controls, which were normalized following phototherapy treatment, apart from serum IL\u201015R\u03b1, which remained elevated. Controlling IL\u201015\/IL\u201015R\u03b1 expression is a newly proposed mechanism of action of phototherapy in MF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12938","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T17:59:05Z","timestamp":1703872745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimation of serum and tissue level of interleukin\u201015 (IL\u201015) and IL\u201015 receptor alpha (IL\u201015R\u03b1) in mycosis fungoides before and after phototherapy: An interventional cohort study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9929-5413","authenticated-orcid":false,"given":"Rania M","family":"Mogawer","sequence":"first","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"Youssef","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kholoud","family":"Helmy","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan","family":"Emad","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat","family":"Shaker","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Orabi","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2018.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.04910"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(85)70075-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.06.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102780"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.2240"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155258"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3645"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100919-023531"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.1.252.413k08_252_258"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04192.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095182"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1297"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2000.009004248.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.28256"},{"key":"e_1_2_10_18_1","unstructured":"Hair follicle\u2010derived IL\u20107 and IL\u201015 mediate skin\u2010resident memory T cell homeostasis and lymphoma \u2013 PubMed.https:\/\/pubmed.ncbi.nlm.nih.gov\/26479922\/. 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