{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:24:30Z","timestamp":1789759470233,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several treatment modalities are available for the treatment of vitiligo due to the lack of a uniformly effective therapy. Topical latanoprost 0.005% is an effective topical treatment. Fractional CO<jats:sub>2<\/jats:sub> laser alone or combined with platelet\u2010rich plasma (PRP) has been proposed as effective adjunctive therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to compare the efficacy of topical latanoprost 0.005% (Ioprost\u00ae, Orchidia, Egypt) combined with either add\u2010on fractional CO<jats:sub>2<\/jats:sub> laser or fractional CO<jats:sub>2<\/jats:sub>\u2010PRP versus topical latanoprost monotherapy in the treatment of localized stable vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>The study included 60 patients randomly assigned into three equal groups. Group A patients received topical latanoprost drops only. Group B patients received topical latanoprost drops and fractional CO<jats:sub>2<\/jats:sub> laser sessions at 2\u2010week interval for 3\u2009months. Group C patients received topical latanoprost drops and fractional CO<jats:sub>2<\/jats:sub> laser sessions combined with PRP at a 2\u2010week interval for 3\u2009months. The mean improvement score by the physician was calculated 4\u2009months after the start of the study. Punch skin biopsies were obtained before treatment and 4\u2009months from the beginning of the study and stained with H&amp;E and HMB\u201045 antibody for evaluation of pigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant clinical improvement of vitiligo lesions with significant increase of re\u2010pigmentation were reported in the three treated groups. Latanoprost in combination with fractional CO<jats:sub>2<\/jats:sub> and PRP was associated with more significant therapeutic outcomes than either combined latanoprost and fractional CO<jats:sub>2<\/jats:sub> or latanoprost alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser\u2010PRP enhances the therapeutic efficacy of latanoprost 0.005% in the treatment of localized stable vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12944","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T04:54:19Z","timestamp":1704948859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A triple combination of latanoprost, fractional CO<sub>2<\/sub> laser, and platelet\u2010rich plasma in localized vitiligo: A clinical and histopathologic 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