{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:02:06Z","timestamp":1768986126930,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The etiology of vitiligo has not been completely elucidated. Recently, 25\u2010hydroxyvitamin D (25(OH)D) and IL\u201033 levels were found to be associated with the development of the vitiligo. The aim was to assess relationship between 25(OH)D, IL\u201033 levels, and clinical improvement after narrow\u2010band UVB treatment in vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with vitiligo who underwent at least 48 sessions of narrow\u2010band UVB treatment were included in this study. Age, gender, smoking status, family history of vitiligo, type of vitiligo, body surface area affected by vitiligo, and vitiligo activity were recorded. 25(OH)D and IL\u201033 were measured and compared at baseline, second month, and fourth month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients with vitiligo and 20 healthy controls were included in this study. The mean baseline 25(OH)D level of vitiligo group was statistically significantly lower than the control group's (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The mean baseline IL\u201033 level was higher in vitiligo group with no statistically significantly difference (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). The increase in 25(OH)D level and the decrease in vitiligo\u2010affected body surface area were found to be statistically significant during treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The mean IL\u201033 levels were found to be lower at the second and fourth month compared to baseline. However, there were no statistical significance (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low levels of 25(OH)D are thought to play a role in the etiopathogenesis of vitiligo. 25(OH)D increase due to phototherapy may have a role in repigmentation independently from the direct effect of narrow\u2010band UVB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12947","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T04:20:31Z","timestamp":1705638031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The correlation analysis between alterations of serum vitamin D, IL\u201033 levels, and clinical improvement after narrow\u2010band UVB treatment in vitiligo patients: A case\u2013control 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