{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:44:23Z","timestamp":1753879463205,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Mycosis fungoides (MF) is the most common variant of cutaneous T\u2010cell lymphomas primarily involving the skin. Early\u2010stage MF is characterised by non\u2010specific skin lesions and non\u2010diagnostic biopsies. While skin\u2010focused treatments, such as PUVA and narrowband UVB (nbUVB), are the most frequently recommended treatments, the UVA1 efficacy has been researched in recent years. The purpose of this study was to evaluate the clinical, histopathological and immunohistochemical aspects of UVA1 treatment in patients with early\u2010stage MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The modified severity weighted assessment scale (mSWAT) was used for total skin body scoring before and after treatment. Skin punch biopsies were taken from the patients before and after treatment. UVA1 therapy was performed five times each week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 26 patients with early\u2010stage MF. The total number of UVA1 sessions varied between 15 and 34. Complete response was observed in 8 (30.8%) of 26 patients (30.8%). The median mSWAT score decreased statistically significantly from 7.1 to 2.0 after treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Histopathological complete response was observed in 2 (9.5%) of 21 patients. A statistically significant decrease in dermal interstitial infiltrate was observed on histopathological examination after treatment (<jats:italic>p<\/jats:italic>\u2009=\u2009.039). Epidermal CD4\/CD8 levels decreased statistically significantly higher from a median of 2.5\u20131.2 in the complete clinical response group after treatment (<jats:italic>p<\/jats:italic>\u2009=\u2009.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to our results, UVA1 treatment has an effect on early\u2010stage MF in terms of clinical, histopathological and immunohistochemistry.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12951","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T05:10:30Z","timestamp":1706332230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, histopathological and immunohistochemical evaluation of ultraviolet A1 treatment in <scp>early\u2010stage<\/scp> mycosis fungoides"],"prefix":"10.1111","volume":"40","author":[{"given":"Nuray","family":"Keskin","sequence":"first","affiliation":[{"name":"Dermatology Department Yenimahalle Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berkay","family":"Temel","sequence":"additional","affiliation":[{"name":"Dermatology Department Ankara Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Ad\u0131\u015fen","sequence":"additional","affiliation":[{"name":"Dermatology Department Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Burhan","family":"Aksakal","sequence":"additional","affiliation":[{"name":"Dermatology Department Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Acar","sequence":"additional","affiliation":[{"name":"Pathology Department \u00d6mer Halisdemir University Training and Research Hospital  Ni\u011fde Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Erdem","sequence":"additional","affiliation":[{"name":"Pathology Department Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1182\/blood-2018-11-881268"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1182\/blood-2004-09-3502"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1056\/NEJMra032810"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1016\/j.jaad.2005.08.057"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1111\/j.1468-3083.2004.00937.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1182\/blood-2016-01-643569"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1016\/j.ad.2016.08.009"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1111\/ced.12001"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.3389\/fonc.2019.00260"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.21037\/cco.2018.11.03"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/j.clindermatol.2013.01.011"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1111\/j.1365-2230.2011.04256.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1016\/j.jaad.2015.09.033"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1309\/AJCPOBDP2OQAJ5BR"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1182\/blood-2007-02-072389"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1111\/j.1468-3083.2006.01635.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1200\/JCO.2010.32.0630"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1182\/blood-2007-03-055749"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1016\/S0190-9622(99)70405-6"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1111\/php.12253"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1159\/000458149"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1111\/ajd.13321"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_1","DOI":"10.5021\/ad.2013.25.1.104"},{"doi-asserted-by":"publisher","key":"e_1_2_10_25_1","DOI":"10.5021\/ad.2010.22.1.1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_26_1","DOI":"10.1067\/mjd.2001.110896"},{"doi-asserted-by":"publisher","key":"e_1_2_10_27_1","DOI":"10.1067\/mjd.2000.108370"},{"key":"e_1_2_10_28_1","first-page":"978","article-title":"Immunohistochemical analysis of mycosis fungoides on paraffin\u2010embedded tissue sections","volume":"11","author":"Izban KF","year":"1998","journal-title":"Mod Pathol"},{"doi-asserted-by":"publisher","key":"e_1_2_10_29_1","DOI":"10.1111\/j.1600-0560.1999.tb01824.x"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:26:37Z","timestamp":1706613997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/phpp.12951"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12951","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"type":"print","value":"0905-4383"},{"type":"electronic","value":"1600-0781"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12951"}}