{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:03:33Z","timestamp":1784322213062,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Narrowband ultraviolet B (NB\u2010UVB) phototherapy promotes stability and repigmentation in vitiligo. No studies have compared targeted NB\u2010UVB with whole\u2010body NB\u2010UVB in treatment of acral vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This randomized split\u2010body study compared whole\u2010body NB\u2010UVB with targeted NB\u2010UVB in inducing stability and repigmentation in acral vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients with bilaterally symmetrical acral vitiligo lesions (distal to elbows and knees) were recruited. Patients received whole\u2010body NB\u2010UVB treatment, with one hand and one foot shielded until elbow and knee, followed by targeted NB\u2010UVB treatment on the shielded side. Patients were assessed at 4\u2010week intervals for 24\u2009weeks using Vitiligo Disease Activity (VIDA) score, Vitiligo Skin Activity Score (VSAS), Vitiligo Area Scoring Index (determined through fingertip method, using the method to calculate facial\u2010VASI) and degree of repigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u2009weeks, 87.5% of patients achieved a VIDA score of 3, with none having active disease at 24\u2009weeks. Over 50% repigmentation was observed in 42.2% and 37.5% of limbs in whole\u2010body and targeted groups, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.95). No improvement in F\u2010VASI scores of hands and feet (distal to wrist and ankles) was noted with either modality over the 24\u2010week period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed comparable repigmentation rates between whole\u2010body and targeted NB\u2010UVB groups. Limited effectiveness of phototherapy in repigmentation of hands and feet underscores an important therapeutic gap.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12960","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T04:54:35Z","timestamp":1710392075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Whole\u2010body and targeted narrowband ultraviolet B phototherapy effectively stabilize acral vitiligo with negligible repigmentation beyond wrists and ankles: Results from a split\u2010body randomized controlled trial"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9578-4691","authenticated-orcid":false,"given":"Anish","family":"Thind","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh 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Sendhil","family":"Kumaran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh 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