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These immune changes are involved in skin carcinogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether nicotinamide riboside and\/or pterostilbene administered systemically inhibits inflammatory and immune effects of exposure to mid\u2010range ultraviolet radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To examine UVB radiation\u2010induced inflammatory effects, mice were fed standard chow\/water, 0.04% pterostilbene in chow and 0.2% nicotinamide riboside in drinking water, diet with nicotinamide riboside alone, or diet with pterostilbene alone. After 4\u2009weeks, mice were exposed to UVB radiation (3500\u2009J\/m<jats:sup>2<\/jats:sup>), and 24\u2010\/48\u2010h ear swelling was assessed. We also asked if each agent or the combination inhibits UVB radiation suppression of contact hypersensitivity in two models. Mice were fed standard diet\/water or chow containing 0.08% pterostilbene, water with 0.4% nicotinamide riboside, or both for 4\u2009weeks. Low\u2010dose: Half the mice in each group were exposed on the depilated dorsum to UVB radiation (1700\u2009J\/m<jats:sup>2<\/jats:sup>) daily for 4\u2009days, whereas half were mock\u2010irradiated. Mice were immunized on the exposed dorsum to dinitrofluorobenzene 4\u2009h after the last irradiation, challenged 7\u2009days later on the ears with dinitrofluorobenzene, and 24\u2010h ear swelling assessed. High dose: Mice were treated similarly except that a single dose of 10,000\u2009J\/m<jats:sup>2<\/jats:sup> of radiation was administered and immunization was performed on the unirradiated shaved abdomen 3\u2009days later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nicotinamide riboside and pterostilbene together inhibited UVB\u2010induced skin swelling more than either alone. Pterostilbene alone and both given together could inhibit UVB\u2010induced immune suppression in both the low\u2010dose and high\u2010dose models while nicotinamide riboside alone was more effective in the low\u2010dose model than the high\u2010dose model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nicotinamide riboside and pterostilbene have protective effects against UVB radiation\u2010induced tissue swelling and immune suppression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12961","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T05:43:27Z","timestamp":1714196607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of <scp>UVB<\/scp> radiation\u2010induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene"],"prefix":"10.1111","volume":"40","author":[{"given":"Verena","family":"Isak","sequence":"first","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan","family":"Azizi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi K.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devina","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakir","family":"Bulmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella S.","family":"Aivazi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan W.","family":"Dellinger","sequence":"additional","affiliation":[{"name":"Elysium Health, Inc.  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