{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:52:47Z","timestamp":1764240767410,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In previous studies, the 308\u2010nm light\u2010emitting diode (LED) has been proven safe and effective for treating vitiligo. However, direct comparisons between the 308\u2010nm LED and 308\u2010nm excimer lamp (308\u2010nm MEL) for the treatment of vitiligo are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of the 308\u2010nm LED and 308\u2010nm MEL for treating nonsegmental stable vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This randomized controlled trial was conducted between January 2018 and August 2023. Enrolled patients were randomly assigned to either the 308\u2010nm LED or the 308\u2010nm MEL groups, both receiving 16 treatment sessions. Adverse events that occurred during the treatment were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 269 stable vitiligo patches from 174 patients completed the study. A total of 131 lesions were included in the 308\u2010nm LED group, and 138 lesions were included in the 308\u2010nm MEL group. After 16 treatment sessions, 38.17% of the vitiligo patches in the 308\u2010nm LED group achieved repigmentation of at least 50% versus 38.41% in the 308\u2010nm MEL group. The two devices exhibited similar results in terms of efficacy for a repigmentation of at least 50% (<jats:italic>p<\/jats:italic>\u2009=\u2009.968). The incidence of adverse effects with the two phototherapy devices was comparable (<jats:italic>p<\/jats:italic>\u2009=\u2009.522).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of vitiligo with the 308\u2010nm LED had a similar efficacy rate to the 308\u2010nm MEL, and the incidence of adverse effects was comparable between the two devices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12972","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T08:19:12Z","timestamp":1715847552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparing the efficacy of 308\u2010nm light\u2010emitting diode and 308\u2010nm excimer lamp for treating vitiligo: A randomized controlled trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Yu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuohong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.048"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102932"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.2787"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.06.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12740"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.01.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12777"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21754"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000151"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01413.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11008.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.05.009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00395-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23198"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000125"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21426"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14260"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000128"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22791"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2584-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00752-6"}],"container-title":["Photodermatology, Photoimmunology &amp; 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