{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:23:04Z","timestamp":1773166984667,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8227120662"],"award-info":[{"award-number":["8227120662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872541"],"award-info":[{"award-number":["81872541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Existing phototherapies are ineffective for treating patients with vitiligo with complete leukotrichia. We compared the efficacy of reverse perilesional irradiation, during which only the lesional areas are covered, with conventional narrowband ultraviolet B (NB\u2010UVB) home phototherapy for repigmentation of non\u2010segmental vitiligo in patients with complete leukotrichia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 12\u2010week, open\u2010label, double\u2010arm, multicenter clinical trial, with a total of 121 patients with non\u2010segmental vitiligo who were randomly divided into two groups (both received topical tacrolimus): the conventional NB\u2010UVB irradiation (CI) and reverse perilesional NB\u2010UVB irradiation (RI) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference in improvement from baseline was observed in the RI group compared with the findings in the CI group (\u221230.8%\u2009\u00b1\u200911.8% vs. \u221225.5%\u2009\u00b1\u200911.05%, respectively [<jats:italic>p<\/jats:italic>\u2009=\u2009.010]; pair\u2010wise comparison <jats:italic>p<\/jats:italic>\u2009=\u2009.900 at week 4, <jats:italic>p<\/jats:italic>\u2009=\u2009.104 at week 8, and <jats:italic>p<\/jats:italic>\u2009=\u2009.010 at week 12). At week 12, the average percentage change from baseline of leukotrichia in the irradiation area significantly decreased from 100% to 82.2%\u2009\u00b1\u200913.65% in the RI group, and from 100% to 88.7%\u2009\u00b1\u20099.64% in the CI group (<jats:italic>p<\/jats:italic>\u2009=\u2009.027). Adverse events were minor, including desquamation, dryness, erythema, and blisters. No severe or lasting side effects were observed during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RI mediated better repigmentation of vitiligo with complete leukotrichia than CI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12974","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T18:03:55Z","timestamp":1715364235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel reverse perilesional home phototherapy can promote the repigmentation of vitiligo patches with complete leukotrichia: A 12\u2010week, open\u2010label, double\u2010arm, multicenter, randomized clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Na","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu 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of Dermatology Taicang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Changshu Second People's Hospital  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jiangyan Dermatology Hospital  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lebin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu 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