{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:31:44Z","timestamp":1783207904996,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>UVA\u20101 phototherapy was first used to treat atopic dermatitis and afterwards to several other skin diseases. The contribution of UVA\u20101 in human photocarcinogenesis, skin photoaging, immune suppression, and hyperpigmentation is now well established. The actual contribution of UVA\u20101 radiation to the development of malignant melanoma (MM) in humans cannot be excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of the study is to evaluate the risk of developing skin cancers (non\u2010melanoma skin cancers (NMSCs) and MM) in patients treated with UVA\u20101 phototherapy with a 5\u2010year dermatological follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study with 31 patients with morphea and atopic dermatitis treated with medium dose UVA\u20101 phototherapy (34\u2009J\/cm<jats:sup>2<\/jats:sup>). All enrolled patients underwent an oncologic prevention visit annually with a 5\u2010year follow\u2010up with clinical evaluation of the entire skin surface.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 5\u2010year follow\u2010up, we recorded a case of basal cell carcinoma (BCC) in the cervical region and one case of MM on the back (pT1a). In both cases, the patients were female and affected by morphea. The Glogau 3 group is prevalent (42%), which is consistent with moderate to severe aging; the data appear to be compatible with the age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study attests that medium\u2010dose UVA\u20101 phototherapy does not increase the risk of developing skin tumors and that UVA\u20101 phototherapy is not a worsening factor of facial photoaging. The main limitation of the study is the small sample size, avoiding to obtain statistically significant values. It was not possible to analyze individually the actual daily sun exposure during the 5\u2010year observation period and to correlate it in terms of time and tumor development. Further studies with large sample sizes will be needed to confirm our data. Our study reaffirms how the dermatological examination performed annually is essential in the follow\u2010up of patients undergoing this type of therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12975","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T17:58:56Z","timestamp":1716573536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Carcinogenic risk in patients treated with <scp>UVA<\/scp>\u20101 phototherapy: A 5\u2010year retrospective study"],"prefix":"10.1111","volume":"40","author":[{"given":"Davide","family":"Cosetti","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical and Neurological Science, Dermatology Section S. 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