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It is well known that prolonged exposure to solar radiation leads to acute and chronic complications, such as erythema, accelerated skin aging, proinflammatory and procarcinogenic effects, and eye damage, among others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A better understanding of the molecules that can protect against ultraviolet radiation and their effects will lead to improvements in skin health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of these effects of the sunlight are modulated by oxidative stress and proinflammatory mechanisms, therefore, the supplementation of substances that can regulate and neutralize reactive oxygen species would be beneficial for skin protection. Current evidence indicates that systemic photoprotection should be used as an adjunctive measure to topical photoprotection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral photoprotectors are a promising option in improving protection against damage induced by UVR, as they contain active ingredients that increase the antioxidant effects of the body, complementing other photoprotection measures. We present a review of oral photoprotectors and their effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12985","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:33:58Z","timestamp":1717745638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sunproofing from within: A deep dive into oral photoprotection strategies in dermatology"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-4294","authenticated-orcid":false,"given":"Dan","family":"Hartmann","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universidad Finis Terrae  Santiago Chile"},{"name":"Centro Internacional de Estudios Cl\u00ednicos (CIEC) Probity Medical Research  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-9347","authenticated-orcid":false,"given":"Fernando","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Centro Internacional de Estudios Cl\u00ednicos (CIEC) Probity Medical Research  Santiago Chile"},{"name":"Department of Dermatology Universidad de Chile  Santiago Chile"},{"name":"Department of Dermatology Cl\u00ednica Universidad de los Andes, Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071026"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8080259"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064534"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.10298486.v1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600830"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00188"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-020-00306-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2010.04.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2020.87"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2313"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00044.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.09.040"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08108.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23824.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16030"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.476"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12987"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.11.074"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.11.009"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/579675"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00286.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43630-023-00453-x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17992"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1789047"},{"key":"e_1_2_9_26_1","volume-title":"Sunscreens and Photoprotection. 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