{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:29Z","timestamp":1753879229144,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Interferon (IFN)\u2010a is often used in combination with psoralen plus ultraviolet A (PUVA) in patients with mycosis fungoides (MF) refractory to skin\u2014targeted therapies in early or advanced stages. The main objective is to evaluate the effectiveness of combined PUVA and low\u2010dose IFN\u2010\u03b1\u20102a therapy in patients with early\u2010 and advanced\u2010stage MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010eight patients who received a combination of PUVA twice or thrice a week and INF\u2010a 3 MU thrice a week for at least 3 months were reviewed retrospectively. The treatment response was evaluated as complete remission (CR), partial remission, stable disease, or progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the initiation, the majority of patients (66.2%) had early\u2010stage disease. In 27.9% of cases, this was the initial treatment administered following the diagnosis of MF. The median duration of combination therapy was 11\u2009months. Complete remission was achieved in 45.6% of the patients with an overall response rate of 60.3%. The mean duration of response was 5 months. Complete remission was statistically significantly higher in early\u2010stage patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). No statistically significant correlation was observed between CR and gender, histopathological features, or laboratory parameters. In patients with CR, 80% experienced relapse, significantly higher in early\u2010stage patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). However, there was no significant difference in disease\u2010free survival between early and advanced stages (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study results indicated that PUVA + low\u2010dose INF\u2010a combination therapy was more effective in the early stage than in the advanced stage. Additionally, there was a high relapse rate after the cessation of treatment in patients who achieved CR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12991","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T11:54:59Z","timestamp":1721822099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy of long\u2010term psoralen plus ultraviolet A and low\u2010dose interferon\u2010a combination therapy in mycosis fungoides: A literature review"],"prefix":"10.1111","volume":"40","author":[{"given":"Hatice","family":"\u015eanl\u0131","sequence":"first","affiliation":[{"name":"Department of Dermatology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130ncilay Kalay","family":"Y\u0131ld\u0131zhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0722-2661","authenticated-orcid":false,"given":"Kaan","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara University Faculty of Medicine  Ankara Turkey"},{"name":"Department of Dermatology Alaeddin Yava\u015f\u00e7a State Hospital  Kilis Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-1666","authenticated-orcid":false,"given":"Beng\u00fc Nisa","family":"Akay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00614_10.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90241-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555576475478"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.02.027"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03732.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301491200"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-4-484"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2003.01643.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.1.257"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"issue":"10","key":"e_1_2_9_12_1","first-page":"3578","article-title":"Prospective randomized multicenter clinical trial on the use of interferon \u20102a plus acitretin versus interferon \u20102a plus PUVA in patients with cutaneous T\u2010cell lymphoma stages I and II","volume":"92","author":"Stadler R","year":"1998","journal-title":"Blood"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10706"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00497.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08886.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04011.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15212"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15737"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04833.x"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.12991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T10:24:06Z","timestamp":1722248646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.12991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/phpp.12991"],"URL":"https:\/\/doi.org\/10.1111\/phpp.12991","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"type":"print","value":"0905-4383"},{"type":"electronic","value":"1600-0781"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12991"}}