{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:32:15Z","timestamp":1775219535177,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010acne scars are a common sequela of acne, especially prevalent among young people. Delayed treatment not only affects self\u2010perception of beauty but also affects the mental health of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to investigate the clinical efficacy of microneedle fractional radiofrequency (MFR) combined with botulinum toxin A (BoNT\/A) in managing post\u2010acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study involved 63 adult patients with post\u2010acne scars, divided into two groups: group 1 (<jats:italic>n<\/jats:italic>\u2009=\u200930) and group 2 (<jats:italic>n<\/jats:italic>\u2009=\u200933). Group 1 received treatment with MFR combined with transcutaneous delivery of BoNT\/A, whereas group 2 received treatment with MFR alone. The study observed the clinical outcomes in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on experimental analysis, the combination of MFR with transcutaneous delivery of BoNT\/A demonstrated superior clinical efficacy compared with group 2. There were no significant differences in baseline data or treatment\u2010related pain and adverse reactions between the two groups. However, group 1 exhibited a higher effectiveness rate, lower ECCA score after treatment, higher satisfaction levels, and statistically significant differences compared to group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MFR combined with transcutaneous delivery of BoNT\/A represents an effective and safe alternative for treating acne scars with minimal side effects and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary Statement<\/jats:title><jats:p>Post\u2010acne scars are a common sequela of acne and combination therapy proves beneficial. Microneedle fractional radiofrequency (MFR) combined with transcutaneous delivery of BoNT\/A can be considered an effective and safe alternative for the treatment of acne scars with minimal side effects and complications. It works together through microneedles, radiofrequency, and botulinum toxin. MFR combined with transcutaneous delivery of BoNT\/A is based on the direct action of MFR on acne scars and the use of microneedle to create a transient skin microchannel, facilitating BoNT\/A penetration into the skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.12994","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T15:25:59Z","timestamp":1725636359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of microneedle fractional radiofrequency combined with transcutaneous delivery of botulinum toxin in the management of post\u2010acne scars"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2012-7015","authenticated-orcid":false,"given":"Limin","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery Northern Jiangsu People's Hospital  Yangzhou 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Northern Jiangsu People's Hospital  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuanjie","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Northern Jiangsu People's Hospital  Yangzhou China"},{"name":"Clinical Medical College Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Northern Jiangsu People's Hospital  Yangzhou 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