{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:08:58Z","timestamp":1773965338789,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005790","name":"Thammasat University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (AGA) affects both men and women, characterized by progressive hair thinning. While current treatments like minoxidil and finasteride have efficacy limitations and side effects, low\u2010level light therapy (LLLT) using red or near\u2010infrared light has emerged as a promising alternative. Recent animal studies suggest potential benefits from green LED light, though human data are sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized an innovative LED helmet emitting red and green LED light on respective halves of the frontal scalp, delivering an energy density of 40\u2009J\/cm<jats:sup>2<\/jats:sup> over 20\u2009min. Clinical photography, physician evaluations on a 7\u2010point scale, patient satisfaction, and measurements of hair density and hair diameter were employed. Data were analyzed using linear mixed\u2010effects models, with significance set at <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen participants (47.1% male, 52.9% female, average age 46.47\u2009years) demonstrated notable improvements after 6\u2009months of treatment. Red and green LEDs both significantly increased hair diameter, non\u2010vellus hair density, and satisfaction scores. Notably, the red LED therapy resulted in a statistically significant decrease in vellus hair density and achieved a greater increase in hair diameter compared to the green LED therapy. Minimal adverse effects were reported, primarily consisting of tolerable scalp heat and mild redness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both red and green LED therapies effectively enhanced hair growth, increasing density and thickness over 6\u2009months. Red LED demonstrated superior improvements in specific measures. Consequently, both therapies present safe and viable alternatives for the management of AGA, expanding the repertoire of available treatment options.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.13004","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T15:58:21Z","timestamp":1728143901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Red and Green <scp>LED<\/scp> Light Therapy: A Comparative Study in Androgenetic Alopecia"],"prefix":"10.1111","volume":"40","author":[{"given":"Jiratchaya","family":"Tantiyavarong","sequence":"first","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasin","family":"Charoensuksira","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-5134","authenticated-orcid":false,"given":"Jitlada","family":"Meephansan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"},{"name":"Samitivej Sukhumvit Hospital Bangkok Dusit Medical Services PLC  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirashat","family":"Hanvivattanakul","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossawat","family":"Rayanasukha","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA)  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thitikorn","family":"Boonkoom","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA)  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittipong","family":"Tantisantisom","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA)  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2010.10011.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.20175241"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101741037"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S214907"},{"issue":"7","key":"e_1_2_9_6_1","first-page":"56","article-title":"Adverse Effects and Safety of 5\u2010Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review","volume":"9","author":"Hirshburg J. 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