{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:35:55Z","timestamp":1790026555873,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary palmar hyperhidrosis (PPH) constitutes a distressing dermatologic condition that greatly affects patients' quality of life. Its management still needs to be addressed to find a suitable therapeutic modality that is readily available, cost effective, and gives patients a quite long disease\u2010free period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of fractional CO<jats:sub>2<\/jats:sub> laser as a delivery method for botulinum toxin\u2010A (BTX\u2010A) and aluminum chloride in treating PPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Twenty\u2010four subjects with PPH were treated on both hands with fractional CO<jats:sub>2<\/jats:sub> laser followed on the right hand with topical BTX\u2010A and on the left hand with topical aluminum chloride. Minor's starch\u2013iodine test and Hyperhidrosis Disease Severity Scale (HDSS) were used for evaluation of treatment response and for follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant improvement in HDSS in both groups, but there was no statistically significant difference in the therapeutic response for both modalities. There was a statistically significant longer disease\u2010free period in the BTX\u2010A\u2010treated hands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser\u2010assisted drug delivery (LADD) represents a safe, minimally invasive procedure that enhances the delivery of BTX\u2010A and aluminum chloride, the two most widely used agents for treating PPH, with a comparable anhidrotic response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.13006","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T18:04:29Z","timestamp":1728583469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fractional <scp>CO<sub>2<\/sub><\/scp> Laser\u2010Assisted Delivery of Botulinum Toxin\u2010A Versus Aluminum Chloride in Treatment of Primary Palmar Hyperhidrosis"],"prefix":"10.1111","volume":"40","author":[{"given":"Manal","family":"Elsayed","sequence":"first","affiliation":[{"name":"Dermatology, Venereology &amp; Andrology Department Zagazig University Hospitals, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheir","family":"Ghonemy","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology &amp; Andrology Department Zagazig University Hospitals, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najat","family":"Sheneeb","sequence":"additional","affiliation":[{"name":"Dermatology Department Almergeb University  Al\u2010Khums Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5311-1578","authenticated-orcid":false,"given":"Mona","family":"Elradi","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology &amp; Andrology Department Zagazig University Hospitals, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"NICE \u201cIntroduction and Current Guidance: Hyperhidrosis: Oxybutynin: Advice \u201d(n.d.) accessed June 21 2023 https:\/\/www.nice.org.uk\/advice\/es10\/chapter\/introduction\u2010and\u2010current\u2010guidance."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15937"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.11.042"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2014.01.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2009.01364.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.202"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010013\u20100201\u20102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0149\u20102918(03)90041\u20105"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010020\u201003064\u20105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000002901"},{"key":"e_1_2_8_12_1","first-page":"1167","article-title":"An Alternative to Treat Palmar Hyperhidrosis: Use of Oxybutynin","volume":"26","author":"Wolosker N.","year":"2011","journal-title":"Clinical Autonomic Research"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0264-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.09018.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2008.00441.x"},{"issue":"3","key":"e_1_2_8_16_1","first-page":"641","article-title":"The Effect and Persistency of 1% Aluminum Chloride Hexahydrate Iontophoresis in the Treatment of Primary Palmar Hyperhidrosis","volume":"10","author":"Kalantari K. K.","year":"2011","journal-title":"Iran Journal of Pharamcology Research"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16781"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.13006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T13:22:33Z","timestamp":1733318553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.13006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/phpp.13006"],"URL":"https:\/\/doi.org\/10.1111\/phpp.13006","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2024-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13006"}}