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However, evidence regarding the efficacy of LED for post\u2010inflammatory erythema (PIE) and post\u2010inflammatory hyperpigmentation (PIH) is limited. The aim of this study was to explore the effect of medical LED (830\u2009nm and 590\u2009nm) in the prevention and treatment of PIE and PIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The in\u00a0vivo PIE\/PIH model was simplified to erythema and pigmentation reaction after acute UVB exposure. 308\u2009nm LED light (225 or 270\u2009mJ\/cm<jats:sup>2<\/jats:sup>) was induced in\u00a0vivo in the PIE\/PIH model on the thigh of ten healthy subjects. Every subject received therapeutic and preventive irradiation (<jats:italic>n<\/jats:italic>\u2009=\u200910 in each group). 830\u2009nm (60\u2009J\/cm<jats:sup>2<\/jats:sup>) and 590\u2009nm LEDs (20\u2009J\/cm<jats:sup>2<\/jats:sup>) were irradiated, respectively. For therapeutic irradiation, the PIE\/PIH model was induced on D1, and LEDs were irradiated on D0, 1, 3, 6 and 8. For preventive irradiation, LEDs were irradiated on D0, 1, 3, 6, and 8 and the PIE\/PIH model was induced on D9. Erythema index (EI), melanin index (MI), transdermal water loss (TEWL), and C\u2010Cube photography were measured during 10\u2010day follow\u2010up visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For therapeutic irradiation, \u0394EI and \u0394MI in the 830\u2009nm treatment group were significantly lower than in the control group (\u0394EI: 9.30 vs. 11.52, <jats:italic>p<\/jats:italic>\u2009=\u20090.027; \u0394MI: 7.79 vs. 9.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.026). No significant difference was found between the 590\u2009nm treatment group and the control group in \u0394EI or \u2206MI (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). For preventive irradiation, \u0394EI in the 830\u2009nm prevention group and the 590\u2009nm prevention group were both significantly lower than the control group (830\u2009nm: 9.85 vs. 19.90, <jats:italic>p<\/jats:italic>\u2009=\u20090.001; 590\u2009nm: 12.50 vs. 19.90, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). No significant difference was found between the two prevention LED groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both 830\u2009nm and 590\u2009nm LEDs showed preventive effects for PIE, and 830\u2009nm LEDs could effectively improve PIE and PIH.<\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1111\/phpp.70003","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T16:50:51Z","timestamp":1738601451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Therapeutic and Preventive Effects of Light\u2010Emitting Diode (<scp>LED<\/scp>) for Post\u2010Inflammatory Erythema and Hyperpigmentation: A Pilot 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital, Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leihong Flora","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital, Fudan University  Shanghai People's Republic of 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