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Numerous studies have shown that the microecosystem of sebaceous glands and <jats:italic>Cutibacterium acnes<\/jats:italic> play key roles in its pathogenesis. Antibiotics targeting <jats:italic>C.\u2009acnes<\/jats:italic> have been widely used in acne treatment, but the growing prevalence of antibiotic resistance has become alarming. Further research into the microecosystem of sebaceous glands and the role of specific <jats:italic>C.\u2009acnes<\/jats:italic> phylotypes in acne pathogenesis has led to a paradigm shift in acne treatment. Currently, non\u2010antibiotic therapies such as light therapy and laser therapy are becoming increasingly popular, opening up new opportunities in acne management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies on the microecosystem of sebaceous glands associated with acne and the effects of light and laser therapies on the microecosystem in acne treatment were retrieved from the PubMed database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dysbiosis of the microecosystem of the pilosebaceous unit is closely related to the pathogenesis of acne. Light and laser therapies have an impact on the microecosystem of the pilosebaceous unit in acne treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Light and laser therapies are the popular alternative options in acne treatment. The mechanisms of their effect on the microecosystem of sebaceous glands are not completely clear and require further research, especially for laser therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.70005","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T05:44:26Z","timestamp":1735969466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Light and Laser Therapies on the Microecosystem of Sebaceous Glands in Acne Treatment"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-6527","authenticated-orcid":false,"given":"Jiaoxiong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Burn Huangpu People's Hospital of Zhongshan  Zhongshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2231-1418","authenticated-orcid":false,"given":"Shengbo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dermatology Hospital of Southern Medical University (Guangdong Provincial Dermatology Hospital)  Guangzhou Guangdong China"},{"name":"Department of Dermatology The Second People's Hospital of Foshan (Affiliated Foshan Hospital of Southern Medical University)  Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6895-3123","authenticated-orcid":false,"given":"Zhengzheng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dermatology Hospital of Southern Medical University (Guangdong Provincial Dermatology Hospital)  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5646-9261","authenticated-orcid":false,"given":"Wen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dermatology Hospital of Southern Medical University (Guangdong Provincial Dermatology Hospital)  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-3807","authenticated-orcid":false,"given":"Wanting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3154-7664","authenticated-orcid":false,"given":"Niangqiao","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hui Ya Hospital of The First Affiliated Hospital, Sun Yat\u2010Sen University  Huizhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0754-0738","authenticated-orcid":false,"given":"Liuhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Luohu People's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-2096","authenticated-orcid":false,"given":"Renliang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Surgery and Dermatoma Dermatology Hospital of Southern Medical University (Guangdong Provincial Dermatology Hospital)  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-677X","authenticated-orcid":false,"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010018\u201000417\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.42.100188.002301"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189846"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201025436\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19540"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113071"},{"key":"e_1_2_9_8_1","volume-title":"StatPearls [Internet]","author":"Vest B. 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