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Comprehensive information on pharmaceutical treatments and skin cancer occurrence was obtained through national registries. Drugs with photosensitizing properties were grouped according to the Anatomical Therapeutic Chemical system in nine groups, and associations between the use of such drugs were investigated using multivariable Cox regression analysis. The number of retrieved daily doses was analyzed to test the dose\u2013response relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hormone replacement therapy significantly increased the risk of BCC (hazard ratio [HR] 1.24; 95% confidence interval [CI]: 1.11\u20131.39), cSCC (HR 1.23; 95% CI: 1.03\u20131.47) and cM (HR 1.31; 95% CI: 1.01\u20131.69), with estrogen driving this risk. There was a trend of increased risk of BCC and cM with higher doses of estrogen treatment. Subgroup analysis among those using diuretics showed that loop diuretics were associated with increased cSCC risk (HR 1.6; 95% CI: 1.3\u20132.0), including a positive association between risk and dose. Furthermore, increased risks of BCC (HR 1.25; 95% CI: 1.09\u20131.44) and cM (HR 1.41; 95% CI: 1.03\u20131.93) were associated with thiazide use. NSAIDs showed a possible curvilinear association to BCC and cSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Estrogen treatment increased the risk of all investigated skin cancers. Among those using diuretics, loop diuretics increased the risk of cSCC, and thiazide use increased the risk of BCC. We suggest that physicians should advise female patients prescribed estrogen, thiazides, or loop diuretics to limit their sun exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.70013","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T03:39:31Z","timestamp":1742355571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Photosensitizing Drugs and Risk of Skin Cancer in Women\u2014A Prospective Population\u2010Based Study"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-1301","authenticated-orcid":false,"given":"Gustav Boelsgaard","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Dermatology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Lund University Skin Cancer Research Group, Dermatology, Department of Clinical Sciences, Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Kappelin","sequence":"additional","affiliation":[{"name":"Lund University Skin Cancer Research Group, Dermatology, Department of Clinical Sciences, Lund Lund University  Lund Sweden"},{"name":"Department of Dermatology Landskrona Hospital  Landskrona Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Sandgren","sequence":"additional","affiliation":[{"name":"Clinical Studies Sweden\u2014Forum South Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Lund University Skin Cancer Research Group, Dermatology, Department of Clinical Sciences, Lund Lund University  Lund Sweden"},{"name":"Department of Dermatology Helsingborg Hospital  Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Ingvar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Lund University Skin Cancer Research Group, Dermatology, Department of Clinical Sciences, Lund Lund University  Lund 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