{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:32:22Z","timestamp":1781623942503,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2022YFQ0055"],"award-info":[{"award-number":["2022YFQ0055"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea, a prevalent chronic inflammatory skin condition primarily affecting the central facial convexities, is categorized into four clinical subtypes: erythematotelangiectatic rosacea (ETR), papulopustular rosacea (PPR), phymatous rosacea (PhR), ocular rosacea (OR). While ultraviolet (UV) radiation is recognized as a risk factor for rosacea, the differential skin sensitivity to UVA and\/or UVB between healthy individuals and rosacea patients remains ambiguous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study comprised 70 patients diagnosed with rosacea and 100 healthy controls. The minimal erythema doses (MED\u2010UVA and MED\u2010UVB) were ascertained using an SUV\u20102000 solar UV simulator. A comparative analysis was conducted on the MED\u2010UVA and MED\u2010UVB results between the rosacea patient group and the healthy control group, as well as among rosacea patients with varying clinical subtypes. Furthermore, the correlation between MED values in rosacea patients and factors such as age, skin type, antinuclear antibodies (ANA), and the Clinical Erythema Assessment (CEA) scale was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison to the healthy control group, the rosacea group demonstrated significantly lower MED\u2010UVA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and MED\u2010UVB (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001) values. However, no significant differences were observed in the MED\u2010UVA (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) and MED\u2010UVB (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) values among patients with varying clinical subtypes of rosacea, specifically between ETR and PPR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients diagnosed with rosacea demonstrate a decreased minimal erythema dose to both UVA and UVB, suggesting heightened sensitivity to ultraviolet radiation. Consequently, it is advisable for individuals with rosacea to minimize sun exposure in order to mitigate or prevent exacerbation of the condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.70019","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T10:32:41Z","timestamp":1744626761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patients With Rosacea Exhibit Lower Minimal Erythema Doses to Both <scp>UVA<\/scp> and <scp>UVB<\/scp>"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1669-1276","authenticated-orcid":false,"given":"Rong","family":"Wei","sequence":"first","affiliation":[{"name":"North Sichuan Medical College  Nanchong China"},{"name":"Chengdu Second People's Hospital  Chengdu China"},{"name":"Fushun People's Hospital  Zingong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Chengdu Second People's Hospital  Chengdu China"},{"name":"Cheng Du Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenni","family":"Lei","sequence":"additional","affiliation":[{"name":"Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Feng","sequence":"additional","affiliation":[{"name":"Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083974"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"561","article-title":"Research Progresses on Skin Damage and Its Mechanisms Induced by Solar Radiation","volume":"43","author":"Li H.","year":"2019","journal-title":"International Journal of Radiation Medicine and Nuclear Medicine"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_9_6_1","article-title":"Fitzpatrick Skin Type and Minimal Erythema Dose","volume":"37","author":"Xia M.","year":"2011","journal-title":"International Journal of Dermatology and Venerology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.044"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16206"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.11.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17992"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113981"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03825.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155891"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S134857"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17432"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1484345"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00632-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.09.045"}],"container-title":["Photodermatology, Photoimmunology &amp; 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