{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:07:40Z","timestamp":1754161660304,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Intense pulsed light (IPL) is a Food and Drug Administration\u2010approved device for the management of several dermatologic disorders, including Acne vulgaris (AV). Nicotinamide, a form of vitamin B3, constitutes a possible therapeutic approach for AV. It has powerful anti\u2010inflammatory benefits without the danger of bacterial resistance or systemic adverse effects.<\/jats:p><\/jats:sec>Purpose<\/jats:title>To contrast the efficacy and safety of IPL and topical nicotinamide 4% cream in the management of AV.<\/jats:p><\/jats:sec>Methods<\/jats:title>This comparative work was conducted on 20 participants aged from 18 to 40\u2009years both sexes, with different clinical types of AV. The patients' faces were allocated into two sides: The right side of the face was treated with 4 IPL sessions at two\u2010weeks intervals, while the left side was treated with topical nicotinamide 4% cream twice daily for 2 months. Clinical assessment of acne lesions in all patients was performed before starting treatment and one and 3 months after the last session.<\/jats:p><\/jats:sec>Results<\/jats:title>A significant enhancement of inflammatory acne lesions existed after treatment with IPL and nicotinamide 4% topical cream. A significant variation existed between the two sides of the face after treatment according to the degree of enhancement, in which the IPL showed better improvement than the nicotinamide 4% cream. Moreover, patients were more satisfied with IPL treatment.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IPL seems to be a safe and effective therapy in the management of mild to moderate inflammatory acne and an alternative to other systemic modalities of acne treatment when they are contraindicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phpp.70025","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T23:06:06Z","timestamp":1751670366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Intense Pulsed Light Versus Topical Nicotinamide 4% in Treatment of Acne Vulgaris"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-0640","authenticated-orcid":false,"given":"Hagar Atteya","family":"Al\u2010Sharnoby","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda Hassan","family":"Al\u2010Bakary","sequence":"additional","affiliation":[{"name":"Histology Department, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia Othman","family":"Nassar","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem Adel Mahmoud","family":"Mesbah","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"issue":"16","key":"e_1_2_12_2_1","first-page":"1","article-title":"The Burden of Skin Diseases in China: Global Burden of Disease Study 2019","volume":"31","author":"Kong Y.","year":"2024","journal-title":"Archives of Dermatological Research"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"176","article-title":"Psychiatric Comorbidity in Patients With Acne","volume":"7","author":"Mufaddel A.","year":"2017","journal-title":"Ohio Journal of Public Affairs"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7860\/jcdr\/2016\/16291.8150"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2010.09.005"},{"issue":"12","key":"e_1_2_12_6_1","first-page":"20","article-title":"Safe and Effective Laser Tattoo Removal Using a New Type of Picosecond Laser With Two Wavelengths","volume":"45","author":"Bayer H.","year":"2024","journal-title":"International Journal of Dermatology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.74550"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051536"},{"issue":"25","key":"e_1_2_12_9_1","first-page":"5","article-title":"The Mechanisms of Action of Nicotinamide and Zinc in Inflammatory Skin Disease","volume":"77","author":"Fivenson D. P.","year":"2006","journal-title":"Cutis"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.08.001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12445"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2008.34399.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550252948121"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170410035584"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600717704"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.946405"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2019.1605450"},{"issue":"3","key":"e_1_2_12_18_1","first-page":"22","article-title":"Effective Intense Pulsed Light Protocol in the Treatment of Moderate to Severe Acne Vulgaris of the Chest and Back","volume":"15","author":"Piccolo D.","year":"2022","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"4","key":"e_1_2_12_19_1","first-page":"55","article-title":"An Investigation of Efficacy of Topical Niacinamide for the Treatment of Mild and Moderate Acne Vulgaris","volume":"20","author":"Kaymak Y.","year":"2008","journal-title":"Journal of the Turkish Academy of Dermatology"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12418"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2010.04701.x"}],"container-title":["Photodermatology, Photoimmunology & Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T05:46:06Z","timestamp":1753767966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/phpp.70025"],"URL":"https:\/\/doi.org\/10.1111\/phpp.70025","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"type":"print","value":"0905-4383"},{"type":"electronic","value":"1600-0781"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70025"}}