{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:15:46Z","timestamp":1780596946681,"version":"3.54.1"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phototherapy reduces serum free bilirubin levels but can also cause various short\u2010 and long\u2010term side effects. This meta\u2010analysis examined the potential relationship between phototherapy duration and type, as well as oxidative and inflammatory reactions in newborns with hyperbilirubinemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, the Cochrane Library, Web of Science, and Embase for observational studies published before December 31, 2023. The Quality in Prognostic Studies (QUIPS) tool was used to evaluate the risk of bias. The intervention included the durations (1.5, 12, 24, 36, 48, 72, and &gt;\u200990\u2009h) and types (light\u2010emitting diode (LED), conventional, and intensive) of phototherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 24 observational studies with 1230 newborns were included in the study. Phototherapy increased the increased oxidative stability index. The oxidative indexes decreased after 1.5 or 90\u2009h of phototherapy but increased after 24 or 48\u2009h. Phototherapy increased nitric oxide levels but was associated with reduced total antioxidant capacity and glutathione. Conventional phototherapy reduced antioxidant indices, whereas LED was associated with increased oxidative indices. After 36\u2009h, phototherapy reduced hematocrit levels. Phototherapy increased the secretion of inflammatory mediators by peripheral blood mononuclear cells after 24\u2009h. In addition, conventional phototherapy increased levels of inflammatory mediators in the serum of infants after 72\u2009h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Side effects of phototherapy, such as altered oxidant\/antioxidant status and inflammatory reactions, may vary depending on the type of phototherapy used. However, no clear pattern was observed in the alterations in these oxidative\/inflammatory markers as a function of the duration of phototherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70056","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T07:32:36Z","timestamp":1759131156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Meta\u2010Analysis of the Oxidative and Inflammatory Reactions to the Type and Duration of Phototherapy in Neonates With Jaundice"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7726-2586","authenticated-orcid":false,"given":"Xiaoyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neonatology The First Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Affiliated Haimen Hospital of Xinglin College, Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Outpatient General Hospital of Western Theater of Chinese People's Liberation Army  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Clinical College of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Heilongjiang Provincial Hospital  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2017.78.12.699"},{"key":"e_1_2_10_3_1","unstructured":"Agency for Clinical Innovation \u201cNeonatal Jaundice Identification and Management in Neonates \u226532\u2009Weeks Gestation \u201dGL2016_027 (2016) https:\/\/www1.health.nsw.gov.au\/pds\/ActivePDSDocuments\/GL2016_027.pdf."},{"key":"e_1_2_10_4_1","unstructured":"National Institute for Health and Clinical Care Excellence (NICE) \u201cJaundice in Newborn Babies Under 28\u2009Days \u201dClinical Practice Guideline 98 London; (2010) Updated October 2016."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327111401638"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01891.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/MI.2005.298"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020179"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.12.2551"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v33i5.14359"},{"key":"e_1_2_10_11_1","first-page":"756","volume-title":"Nelson Textbook of Pediatrics","author":"Kliegman R. 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