{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:06:40Z","timestamp":1787062000134,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vitiligo, a common depigmentation disorder, is often treated with phototherapy. 308\u2010nm monochromatic excimer lamp\/laser (308\u2010nm MEL) is typically administered in hospitals, whereas 308\u2010nm light\u2010emitting diodes (308\u2010nm LED) offer a home\u2010based alternative. This study compared the efficacy and safety of home\u2010based 308\u2010nm LED with hospital\u2010based 308\u2010nm MEL in pediatric vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of 75 pediatric vitiligo patients treated with home\u2010based 308\u2010nm LED or hospital\u2010based 308\u2010nm MEL was conducted. Efficacy (repigmentation &gt;\u200950%) and adverse events were evaluated after 16, 32, and 48 sessions. Statistical analyses were performed using SPSS 25.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 48 sessions, hospital\u2010based 308\u2010nm MEL showed higher efficacy rates (79.5%) than home\u2010based 308\u2010nm LED (38.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, efficacy was similar when cumulative doses were comparable (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Adverse events were more frequent in the home\u2010based group (63.9% vs. 30.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029), likely due to cautious dose adjustments. Shorter disease duration and stable disease correlated with better outcomes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Home\u2010based 308\u2010nm LED is a viable alternative to hospital\u2010based 308\u2010nm MEL for pediatric vitiligo when cumulative doses are similar. However, higher adverse events in home\u2010based therapy highlight the need for better patient education and professional guidance. AI and digital platforms could enhance the safety and efficacy of home\u2010based phototherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70059","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:34:42Z","timestamp":1760171682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Retrospective Study to Compare the Efficacy of 308\u2010nm Light\u2010Emitting Diode and 308\u2010nm Monochromatic Excimer Lamp in the Treatment of Pediatric Vitiligo"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-0494","authenticated-orcid":false,"given":"Jingyi","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingxia","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaji","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity  Chongqing 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