{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:46:51Z","timestamp":1787060811934,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>Concerns about fetal safety limit acne treatments during pregnancy. The 308\u2010nm excimer light offers targeted UVB exposure to lesions with less impact on healthy skin compared to whole\u2010body NB\u2010UVB. We assessed the efficacy and safety of lesion\u2010directed excimer light for inflammatory acne in pregnancy, including folate monitoring and obstetric outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center, single\u2010arm pilot study was conducted in 13 pregnant women with inflammatory acne in the second trimester. Lesion\u2010directed 308\u2010nm excimer light was delivered to facial lesions twice weekly for 8\u2009weeks with erythema\u2010guided escalation; serum folate was monitored, and obstetric outcomes were captured prospectively. For assessment of improvement, the Investigator's Global Assessment (IGA) and the Dermatology Life Quality Index (DLQI) were applied. Analyses emphasized estimation with 95% CIs; exploratory patient\u2010reported\/assessor correlations used Spearman's \u03c1 with exact\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both inflammatory and non\u2010inflammatory lesions improved; the primary endpoint showed a 48.3% mean reduction in inflammatory lesions at Week 8, 5\/13 achieved a\u2009\u2265\u20092\u2010grade IGA improvement, and mean DLQI improved by 5.9 points. Serum folate remained within the reference range, and obstetric outcomes were reassuring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Excimer light was associated with clinically meaningful reductions in inflammatory acne lesions with reassuring safety signals and obstetric outcomes. It may be a pregnancy\u2010compatible option when other therapies are limited and merits evaluation in controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70072","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T09:05:53Z","timestamp":1767085553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["308\u2010nm Excimer Light for Inflammatory Acne in Pregnancy: A Prospective Pilot Study"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-9748","authenticated-orcid":false,"given":"Mahmoud A.","family":"Rageh","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6475-7557","authenticated-orcid":false,"given":"Amr Mohammad","family":"Ammar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6879-3728","authenticated-orcid":false,"given":"Sara M.","family":"Mohy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Misr University for Science and Technology  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5223-4632","authenticated-orcid":false,"given":"Muhammad","family":"Mohsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-6603","authenticated-orcid":false,"given":"Kamal","family":"Rageh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-6870","authenticated-orcid":false,"given":"Abeer Attia","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00854-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0895-0"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"180","article-title":"The Effect of Narrowband Ultraviolet B Phototherapy on Serum Folate Level","volume":"12","author":"Shirzadian Kebria A.","year":"2021","journal-title":"Caspian Journal of Internal Medicine"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2023.12.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12964"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14582"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02151.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0164-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00624-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.06.046"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15906"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13634"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.079"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.70033"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16954"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.9240"},{"key":"e_1_2_11_20_1","volume-title":"Acne Vulgaris: Establishing Effectiveness of Drugs Intended to Treat Acne Vulgaris\u2014Guidance for Industry","author":"U.S. Food and Drug Administration, Center for Drug Evaluation and Research","year":"2018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_11_22_1","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0","author":"U.S. Department of Health and Human Services; National Institutes of Health; National Cancer Institute","year":"2017"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107784"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04005-2"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-016-0105-8"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-019-0499-1"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.70072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/phpp.70072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phpp.70072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:02:59Z","timestamp":1769605379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phpp.70072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/phpp.70072"],"URL":"https:\/\/doi.org\/10.1111\/phpp.70072","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70072"}}