{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:19:37Z","timestamp":1789348777007,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phototherapy with narrowband ultraviolet B (UVB) is an effective treatment for vitiligo. However, it requires frequent in\u2010office visits. Self\u2010administered home\u2010based UVB (HBUVB) therapy with a handheld or panel device is an alternative that has received limited research attention. The purpose of this systematic review and meta\u2010analysis is to evaluate the effectiveness and safety of HBUVB in the treatment of vitiligo compared to in\u2010office UVB (IOUVB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Searches were conducted on Medline, Cochrane and Embase from inception until 4th of August, 2024. Studies with primary data of patients being treated with a hand\u2010held UVB device were included in this study. Efficacy as measured in number of patients achieving &gt;\u200950% or &gt;\u200975% repigmentation was the primary study outcome. Secondary outcomes analyzed were cost, adverse events and adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen studies were included with a total of 1341 vitiligo patients. Of these, four studies (148 HBUVB and 143 IOUVB) could be used for the meta\u2010analysis. HBUVB was not inferior to IOUVB at achieving &gt;\u200950% (OR 1.04, 95% CI 0.58\u20131.87) and &gt;\u200975% repigmentation (OR 1.26, 95% CI 0.65\u20132.42). Home\u2010based UVB was not associated with an increase in risk for either erythema or burning sensations when compared to IOUVB. There was a 14% lower rate of discontinuation amongst patients using HBUVB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Significance\/Impact<\/jats:title>\n                    <jats:p>Home\u2010based UVB therapy is not inferior to in\u2010office UVB therapy in efficacy or rate of adverse events and demonstrates favourable treatment adherence. This meta\u2010analysis provides evidence supporting HBUVB as a safe and effective alternative to IOUVB in patients with vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO registration number: (CRD42023478123)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70079","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:00:41Z","timestamp":1773129641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effectiveness of Home\u2010Based Phototherapy in Vitiligo: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-9575","authenticated-orcid":false,"given":"Firdavis","family":"Xireaili","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieu","family":"Ha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9848-1919","authenticated-orcid":false,"given":"Zhao Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Min","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Fairfield Dermatology  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2570-3370","authenticated-orcid":false,"given":"Adrian","family":"Mar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chew","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"},{"name":"Department of Dermatology Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Medicine, School of Translational Medicine Monash University  Melbourne Victoria Australia"},{"name":"Victorian Melanoma Service Alfred Health  Melbourne Victoria Australia"},{"name":"Skin Health Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.09.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(14)60763\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18257"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.2787"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_310_18"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.12.026"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386.ch12"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106215\u201015\u201051"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12495"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19592"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19554"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12974"},{"issue":"3","key":"e_1_2_11_14_1","first-page":"226","article-title":"Treatment of Vitiligo With Hand Held Nbuvb Phototherapy Unit\u2014Study of 50 Patients","volume":"2","author":"Goel S.","year":"2012","journal-title":"International Journal of Institutional Pharmacy and Life Sciences"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_476_19"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378\u20106323.136907"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_604_22"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12462"},{"issue":"2","key":"e_1_2_11_19_1","first-page":"2949","article-title":"Initial Dose of Narrow Band Ultraviolet\u2010B Phototherapy for Indonesian Vitiligo Patients","volume":"21","author":"Dian Ardiana E. 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