{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:03:54Z","timestamp":1779789834490,"version":"3.53.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473523"],"award-info":[{"award-number":["82473523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1408600"],"award-info":[{"award-number":["23ZR1408600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2509001"],"award-info":[{"award-number":["2023YFC2509001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Sensitive skin (SS) is a prevalent condition characterized by exaggerated sensory responses to environmental stimuli. Emerging evidence suggests that light\u2010emitting diode (LED) therapy may alleviate SS symptoms by modulating inflammation and enhancing skin barrier function. This study aimed to evaluate the efficacy and safety of 590\u2009nm yellow LED monotherapy versus the combination of 590\u2009nm and 630\u2009nm red\u2010yellow LED therapy in SS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010center, prospective, randomized controlled trial was conducted on 30 volunteers diagnosed with SS. Participants were randomized into three groups: Group A (control, emollient only), Group B (590\u2009nm yellow light, 10\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , 11\u2009min, thrice weekly), and Group C (590\/630\u2009nm dual light, 30\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , 10\u2009min, thrice weekly). Outcomes were assessed using the Laurent Misery sensitive scale\u201010 (SS\u201010) questionnaire, Thinkview imaging, transepidermal water loss (TEWL), pH value, erythema index (EI), melanin index (MI), and lactic acid sting test (LAST). Participants were evaluated at baseline and at follow\u2010up visits during Weeks\u20092, 4, and 8.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both LED treatment groups showed significant improvements in SS\u201010 scores compared to the control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0025 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The 590\u2009nm LED yellow light treatment markedly reduced EI (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.0282), MI (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.0109), TEWL (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.0479) and showed superior improvements in LAST (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.0013) compared with control, while 590\/630\u2009nm LED irradiation reduced lactic acid sting scores significantly compared with control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0239). No adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LED light therapy, particularly 590\u2009nm yellow light, is a safe and effective modality for alleviating SS symptoms, with dual\u2010wavelength therapy showing complementary benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70090","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:11:43Z","timestamp":1775621503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of 590\u2009Nm and 590\/630\u2009Nm Light\u2010Emitting Diode Therapy for Sensitive Skin: A Prospective Randomized Controlled Trial"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0423-4604","authenticated-orcid":false,"given":"Xuanxuan","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5595-4623","authenticated-orcid":false,"given":"Muyang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1302-5667","authenticated-orcid":false,"given":"Chengfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-219X","authenticated-orcid":false,"given":"Shanglin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2397"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00098"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16000"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02453990"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084483"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14542"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11243949"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.074"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.13735\/j.cjdv.1001\u20107089.202401044"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101870"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201007466\u20103"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20412"},{"issue":"6","key":"e_1_2_12_14_1","first-page":"605","article-title":"A Novel Non\u2010Thermal Non\u2010Ablative Full Panel LED Photomodulation Device for Reversal of Photoaging: Digital Microscopic and Clinical Results in Various Skin Types","volume":"3","author":"Weiss R. 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