{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:04:02Z","timestamp":1779789842262,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is growing evidence that individuals with different skin phototypes require tailored approaches to achieve optimal photoprotection. Individuals with darker skin phototypes are more prone to UVA1\u2010 and visible light\u2010induced pigmentation, whereas lighter phototypes are more susceptible to shorter wavelengths such as UVB and UVA2. Thus, skin phototype is an important determinant of sunscreen efficacy. In the present study, we have asked if ancestry\u2014independent of phototype\u2014is another factor affecting sunscreen efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      (i) To determine the overall photoprotective effects of two sunscreen formulations against UVA1, visible light (VL), and combined visible light\n                      <jats:italic>plus<\/jats:italic>\n                      UVA1, and (ii) to compare the photoprotective efficacy of both products between Han Chinese participants and participants of European ancestry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty healthy volunteers (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200920 Han Chinese;\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200920 of European ancestry), matched for phototype, constitutive pigmentation, gender, and age, were exposed to VL, UVA1, and combined VL\n                      <jats:italic>plus<\/jats:italic>\n                      UVA1 to induce pigmentation responses following standardized irradiation protocols. Skin responses across treated and untreated sites were analyzed using linear mixed\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across all participants, both sunscreen formulations provided significant protection against VL, UVA1, and combined VL\n                      <jats:italic>plus<\/jats:italic>\n                      UVA1. Notably, photoprotective efficacy against UVA1\u2010induced immediate (IPD) and persistent pigment darkening (PPD) differed significantly between individuals of different ancestries, with one formulation showing stronger protection in Han Chinese.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This exploratory study indicates that sunscreen efficacy may differ across ancestries. Thus, sunscreens should not only be tailored to different phototypes but also need to consider ancestry\u2010related factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70094","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:39:32Z","timestamp":1776955172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sunscreen Efficacy Against UVA1\u2010 And Visible Light\u2010Induced Skin Pigmentation Is Influenced by Ancestry"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5581-6428","authenticated-orcid":false,"given":"Florian","family":"Dimmers","sequence":"first","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine  D\u00fcsseldorf Germany"},{"name":"Department of Dermatology, HELIOS Klinikum Krefeld Academic Teaching Hospital of the University of Aachen  Krefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"L\u00fcck","sequence":"additional","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine  D\u00fcsseldorf Germany"},{"name":"Department of Statistics TU Dortmund University  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Better Way (Shanghai) Cosmetics Co. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-1517","authenticated-orcid":false,"given":"Jean","family":"Krutmann","sequence":"additional","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060015008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12537"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15940"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17242"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.95"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00358.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700026200"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01411.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.023"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12783"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12736"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1923"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14153"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00225.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00027.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsct.2024.100042"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.06.006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.1991.tb00561.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.03.012"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.024"},{"key":"e_1_2_11_22_1","volume-title":"R: A Language and Environment for Statistical Computing, 2023","author":"R Core Team","year":"2023"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529876"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_11_25_1","unstructured":"R.Lenth emmeans: Estimated Marginal Means aka Least\u2010Squares Means. 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