{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:19:18Z","timestamp":1787167158389,"version":"build-2736575974"},"reference-count":96,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sunlight is essential for vitamin D synthesis and contributes to mood regulation, but it is also a major risk factor for skin aging and carcinogenesis. While the cutaneous and immune effects of ultraviolet radiation are well documented, its potential impact on brain function remains poorly understood. This review aims to synthesize current evidence on the effects of ultraviolet exposure on the central nervous system, with a particular focus on photoimmunological mechanisms and skin\u2010derived signaling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a narrative review of experimental and clinical studies investigating the systemic and neurological consequences of UV exposure. Findings from photodermatology, immunology, neuroscience, and microbiome research were integrated to examine potential skin\u2010brain interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>UV exposure induces systemic inflammatory responses and immunosuppression, alters the skin microbiome, and modulates circulating neuroactive mediators. These processes are associated with changes in neurotransmitter systems, neuroplasticity, and brain structure in both animal models and human studies. Emerging evidence supports the existence of indirect pathways linking UV\u2010induced skin and immune responses to central nervous system function, including immune and microbiota\u2010related mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, available data suggest that UV radiation may influence brain function indirectly through interconnected skin, immune, and microbiota pathways. As interest in balanced and \u201chealthy\u201d sun exposure increases, further interdisciplinary research is needed to clarify the neurological consequences of UV exposure and to assess its potential implications in photodermatology and photomedicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70097","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:52:07Z","timestamp":1779256327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultraviolet Radiations Impact on the Skin\u2010Brain Axis: A Literature Review of our Current Knowledge"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0086-3903","authenticated-orcid":false,"given":"Mariam","family":"Deriouich","sequence":"first","affiliation":[{"name":"Dermatology Department Caen\u2010Normandie University Hospital  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dompmartin","sequence":"additional","affiliation":[{"name":"Dermatology Department Caen\u2010Normandie University Hospital  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Matthieu","family":"L'Orphelin","sequence":"additional","affiliation":[{"name":"Dermatology Department Caen\u2010Normandie University Hospital  Caen France"},{"name":"Interdisciplinary Research Unit for Cancer Prevention and Treatment, Fran\u00e7ois Baclesse Cancer Centre Universit\u00e9 de Caen Normandie Inserm Anticipe UMR 1086, Normandie Univ  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612222"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"339","article-title":"UV\u2010Radiation, Apoptosis and Skin","volume":"35","author":"Pustisek N.","year":"2011","journal-title":"Collegium Antropologicum"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.20013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108535"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010022\u201001598\u20108"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14033"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/42\/5\/004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.247"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.13224"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10081069"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-46227-7_5"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2015.09.025"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2019.02.006"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44220\u2010023\u201000135\u20108"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.64.e68268"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017\u201003230"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.4.1688"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1934518"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.217"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.238"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940\u20106207.CAPR\u201011\u20100165"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.2007.02632.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14193908"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113816128281314231219113942"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4pp00051j"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.6.769"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.8.3783"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.365"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.59"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001693"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022\u2010202X.2005.23615.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4648"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/2011274015"},{"key":"e_1_2_12_35_1","volume-title":"StatPearls","author":"Rathod D. 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