{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:23:31Z","timestamp":1790396611623,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite scientific documentation of the role of oxidative stress in the pathophysiology of vitiligo, the effectiveness of antioxidants in treating the condition is still debated. The objective of this study was to compare the efficacy of gliadin\u2010protected superoxide dismutase (GP\u2010SOD) in combination with targeted ultraviolet B phototherapy to targeted phototherapy alone for patients with localized vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 6\u2010month, prospective, single\u2010center, comparative study was conducted in 40 vitiligo patients. All patients received an excimer lamp and half, randomly assigned, received in addition GP\u2010SOD. The primary endpoint was the difference between the treatment arms in terms of repigmentation at 6\u2009months, using the VASI (Vitiligo Area Scoring Index). VitiQol was used to assess the quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6\u2009months, GP\u2010SOD\u2009+\u2009UVB and UVB alone groups both demonstrated a significant improvement in VASI, respectively: \u22121.65\u2009\u00b1\u20090.08 (standard error, SE) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and \u22121.14\u2009\u00b1\u20090.08 (SE) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The mean difference between the two groups was 0.51 (95% confidence interval (IC95%) 0.28\u20130.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The VitiQoL improvement difference was 5.59 (IC95% 4.01\u20137.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), indicating a superior improvement in quality of life with the combination treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining GP\u2010SOD with targeted phototherapy significantly increases the effectiveness of phototherapy in repigmenting vitiligo lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/phpp.70105","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:12:46Z","timestamp":1781496766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combination of Oral Gliadin\u2010Protected Superoxide Dismutase With Targeted Phototherapy in Vitiligo: A Prospective, Comparative, Randomized, Single\u2010Blinded Study"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6120-2712","authenticated-orcid":false,"given":"Giovanni","family":"Leone","sequence":"first","affiliation":[{"name":"Photodermatology and Vitiligo Treatment Center Israelite Hospital  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-2076","authenticated-orcid":false,"given":"Clemence","family":"Bertold","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Nice Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7315-2323","authenticated-orcid":false,"given":"Andrea Paro","family":"Vidolin","sequence":"additional","affiliation":[{"name":"Photodermatology and Vitiligo Treatment Center Israelite Hospital  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-9626","authenticated-orcid":false,"given":"Eric","family":"Fontas","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Cimiez Hospital, CHU Nice Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"Thierry","family":"Passeron","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Nice Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire Universit\u00e9 C\u00f4te d'Azur  Nice 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